Heterogeneous Parahydrogen Pairwise Addition to Cyclopropane Full article
| Journal |
ChemPhysChem
ISSN: 1439-4235 , E-ISSN: 1439-7641 |
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| Output data | Year: 2018, Volume: 19, Number: 20, Pages: 2621-2626 Pages count : 6 DOI: 10.1002/cphc.201800690 | ||||||||||||
| Tags | contrast agent; cyclopropane; hydrogenation; hyperpolarization; parahydrogen-induced polarization | ||||||||||||
| Authors |
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| Affiliations |
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Funding (11)
| 1 | Russian Science Foundation | 17-73-20030 |
| 2 | Russian Foundation for Basic Research | 17-54-33037 |
| 3 | National Science Foundation | CHE-1416432 |
| 4 | National Science Foundation | CHE-1416268 |
| 5 | Federal Agency for Scientific Organizations | 0303-2016-0004 |
| 6 | Federal Agency for Scientific Organizations | 0333-2018-0006 (II.1.13.1.) |
| 7 | Federal Agency for Scientific Organizations | 0333-2017-0002 |
| 8 | National Institutes of Health | 1R21EB020323 |
| 9 | National Institutes of Health | 1R21CA220137 |
| 10 | United States Department of Defense | W81XWH-15-1-0271 |
| 11 | United States Department of Defense | W81XWH-15-1-0272 |
Abstract:
Hyperpolarized gases revolutionize functional pulmonary imaging. Hyperpolarized propane is a promising emerging contrast agent for pulmonary MRI. Unlike hyperpolarized noble gases, proton‐hyperpolarized propane gas can be imaged using conventional MRI scanners with proton imaging capability. Moreover, it is non‐toxic odorless anesthetic. Furthermore, propane hyperpolarization can be accomplished by pairwise addition of parahydrogen to propylene. Here, we demonstrate the feasibility of propane hyperpolarization via hydrogenation of cyclopropane with parahydrogen. 1H propane polarization up to 2.4 % is demonstrated here using 82 % parahydrogen enrichment and heterogeneous Rh/TiO2 hydrogenation catalyst. This level of polarization is several times greater than that obtained with propylene as a precursor under the same conditions despite the fact that direct pairwise addition of parahydrogen to cyclopropane may also lead to formation of propane with NMR‐invisible hyperpolarization due to magnetic equivalence of nascent parahydrogen protons in two CH3 groups. NMR‐visible hyperpolarized propane demonstrated here can be formed only via a reaction pathway involving cleavage of at least one C–H bond in the reactant molecule. The resulting NMR signal enhancement of hyperpolarized propane was sufficient for 2D gradient echo MRI of ∼5.5 mL phantom with 1×1 mm2 spatial resolution and 64×64 imaging matrix despite relatively low chemical conversion of cyclopropane substrate.
Cite:
Salnikov O.G.
, Kovtunov K.V.
, Nikolaou P.
, Kovtunova L.M.
, Bukhtiyarov V.I.
, Koptyug I.V.
, Chekmenev E.Y.
Heterogeneous Parahydrogen Pairwise Addition to Cyclopropane
ChemPhysChem. 2018.
V.19. N20. P.2621-2626. DOI: 10.1002/cphc.201800690
WOS
Scopus
РИНЦ
OpenAlex
OpenAlex
AN
PMID
Heterogeneous Parahydrogen Pairwise Addition to Cyclopropane
ChemPhysChem. 2018.
V.19. N20. P.2621-2626. DOI: 10.1002/cphc.201800690
WOS
Scopus
РИНЦ
OpenAlex
OpenAlex
AN
PMID
Files:
Full text from publisher
Dates:
| Submitted: | Jul 18, 2018 |
| Accepted: | Jul 23, 2018 |
| Published online: | Aug 7, 2018 |
| Published print: | Oct 19, 2018 |
Identifiers:
| ≡ Web of science: | WOS:000448062900003 |
| ≡ Scopus: | 2-s2.0-85052951382 |
| ≡ Elibrary: | 41781531 |
| ≡ OpenAlex: | W2884826061 | W2897888484 |
| ≡ Chemical Abstracts: | 2018:1461742 |
| ≡ PMID: | 30039565 |