Study of Hemocompatibility and Endothelial Cell Interaction of Tecoflex-Based Electrospun Vascular Grafts | Sciact - CRIS-system of Boreskov Institute of Catalysis

Study of Hemocompatibility and Endothelial Cell Interaction of Tecoflex-Based Electrospun Vascular Grafts Full article

Journal

International Journal of Polymeric Materials and Polymeric Biomaterials ((invalid ISSN 0367-8369)
ISSN: 0091-4037 , E-ISSN: 1563-535X

Output data

Year: 2019, Volume: 68, Number: 1-3, Pages: 34-43 Pages count : 10 DOI: 10.1080/00914037.2018.1525721

Tags

Electrospinning; vascular graft; polyurethane; gelatin; bivalirudin; HUVEC; hemocompatibility

Authors

Chernonosova Vera S. ^1,2 , Gostev Alexander A. ¹ , Chesalov Yuriy A. ³ , Karpenko Andrey A. ¹ , Karaskov Alexander M. ¹ , Laktionov Pavel P. ^1,2

Affiliations

1	Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Novosibirsk, Russia
2	Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
3	Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

Funding (1)

Russian Science Foundation

17-75-30009

Ensuring long-term functioning and efficient endothelialization of small diameter vascular grafts (VG) is an urgent task of tissue engineering. A solution may be to use electrospun VGs prepared from blends polyurethane with gelatin and/or bivalirudin. Here, properties of 3D matrices were explored by SEM, contact angle measurements and IR spectroscopy, and their interaction with blood and endothelial cells was studied. Introduction of gelatin into matrices enhanced adhesion and proliferation of endotheliocytes and enabled adhesion of platelets, whereas bivalirudin inhibited platelet adhesion while having no negative effect on the adhesion and proliferation of endothelial cells.

Chernonosova V.S. , Gostev A.A. , Chesalov Y.A. , Karpenko A.A. , Karaskov A.M. , Laktionov P.P.
Study of Hemocompatibility and Endothelial Cell Interaction of Tecoflex-Based Electrospun Vascular Grafts
International Journal of Polymeric Materials and Polymeric Biomaterials ((invalid ISSN 0367-8369). 2019. V.68. N1-3. P.34-43. DOI: 10.1080/00914037.2018.1525721 WOS Scopus РИНЦ AN OpenAlex

Submitted:	Jun 13, 2018
Accepted:	Aug 25, 2018
Published online:	Dec 21, 2018
Published print:	Feb 11, 2019

Web of science:	WOS:000467974500005
Scopus:	2-s2.0-85059010446
Elibrary:	37413483
Chemical Abstracts:	2018:2604153
OpenAlex:	W2905776205

DB	Citing
Scopus	15
Elibrary	13
Web of science	15
OpenAlex	19