Large Porous Particles for Respiratory Drug Delivery. Glycine-Based Formulations | Sciact - CRIS-система Института катализа

Large Porous Particles for Respiratory Drug Delivery. Glycine-Based Formulations Научная публикация

Журнал

European Journal of Pharmaceutical Sciences
ISSN: 0928-0987 , E-ISSN: 1879-0720

Вых. Данные

Год: 2017, Том: 110, Страницы: 148-156 Страниц : 9 DOI: 10.1016/j.ejps.2017.05.007

Ключевые слова

Spray freeze-drying Salbutamol Budesonide Glycine Clathrate hydrates Dry powder inhaler formulation Large porous particles

Авторы

Ogienko A.G. ^1,2 , Bogdanova E.G. ² , Trofimov N.A. ³ , Myz S.A. ⁴ , Ogienko A.A. ⁵ , Kolesov B.A. ^1,2 , Yunoshev A.S. ^2,6 , Zubikov N.V. ³ , Manakov A.Yu. ^1,2 , Boldyrev V.V. ^2,4 , Boldyreva E.V. ^2,4

Организации

1	Nikolaev Institute of Inorganic Chemistry SB RAS, Novosibirsk, Russia
2	Novosibirsk State University, Novosibirsk, Russia
3	JSC ‘Nativa’, Moscow, Russia
4	Institute of Solid State Chemistry and Mechanochemistry SB RAS, Novosibirsk, Russia
5	Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
6	Lavrentiev Institute of Hydrodynamics SB RAS, Novosibirsk, Russia

Информация о финансировании (3)

1	Совет по грантам Президента Российской Федерации	СП-1144.2013.4
2	Совет по грантам Президента Российской Федерации	СП-680.2013.4
3	Федеральное агентство научных организаций России	0301-2016-0014 (АААА-А17-117030310274-5)

Large porous particles are becoming increasingly popular as carriers for pulmonary drug delivery with both local and systemic applications. These particles have high geometric diameters (5–30 μm) but low bulk density (~0.1 g/cm3 or less) such that the aerodynamic diameter remains low (1–5 μm). In this study salbutamol and budesonide serve as model inhalable drugs with poor water solubility. A novel method is proposed for the production of dry powder inhaler formulations with enhanced aerosol performance (e.g. for salbutamol-glycine formulation the fine particle fraction (FPF ≤ 4.7 μm) value is 67.0 ± 1.3%) from substances that are poorly soluble in water. To overcome the problems related to extremely poor aqueous solubility of the APIs, not individual solvents are used for spray freeze-drying of API solutions, but organic-water mixtures, which can form clathrate hydrates at low temperatures and release APIs or their complexes as fine powders, which form large porous particles after the clathrates are removed by sublimation. Zwitterionic glycine has been used as an additive to API directly in solutions prior to spray freeze-drying, in order to prevent aggregation of powders, to enhance their dispersibility and improve air-flow properties. The clathrate-forming spray freeze-drying process in the multi-component system was optimized using low-temperature powder X-ray diffraction and thermal analysis.

Ogienko A.G. , Bogdanova E.G. , Trofimov N.A. , Myz S.A. , Ogienko A.A. , Kolesov B.A. , Yunoshev A.S. , Zubikov N.V. , Manakov A.Y. , Boldyrev V.V. , Boldyreva E.V.
Large Porous Particles for Respiratory Drug Delivery. Glycine-Based Formulations
European Journal of Pharmaceutical Sciences. 2017. V.110. P.148-156. DOI: 10.1016/j.ejps.2017.05.007 WOS Scopus РИНЦ CAPlus OpenAlex

Поступила в редакцию:	10 янв. 2017 г.
Принята к публикации:	4 мая 2017 г.
Опубликована online:	4 мая 2017 г.
Опубликована в печати:	15 дек. 2017 г.

Web of science:	WOS:000414696100006
Scopus:	2-s2.0-85018931544
РИНЦ:	31023768
Chemical Abstracts:	2017:779454
OpenAlex:	W2611759838

БД	Цитирований
Scopus	32
Web of science	28
OpenAlex	33