Slow Relaxation During and After Perturbation of Bistable Kinetics of Gene Expression Full article
| Journal |
European Biophysics Journal with Biophysics Letters
ISSN: 0175-7571 , E-ISSN: 1432-1017 |
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| Output data | Year: 2019, Volume: 48, Number: 3, Pages: 297–302 Pages count : 6 DOI: 10.1007/s00249-019-01358-3 | ||||
| Tags | Bistability; Transient kinetics; Gene expression; Mean-feld kinetic equations; Monte Carlo simulations; Drug delivery | ||||
| Authors |
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| Affiliations |
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Funding (2)
| 1 | Federal Agency for Scientific Organizations | 0303-2016-0001 |
| 2 | Stiftelsen för strategisk forskning | IRC15-0065 |
Abstract:
After a short perturbation of a bistable genetic network, it returns to its initial steady state or transits to another steady state. The time scale characterizing such transient regimes can be appreciably longer compared to those of the degradation of the perturbed mRNAs and proteins. The author shows in detail the specifics of this slowdown of the transient kinetics using mean-field kinetic equations and Monte Carlo simulations. Attention is focused on nanocarrier-mediated delivery and release of short non-coding RNA (e.g., miRNA or siRNA) into cells with subsequent suppression of the populations of the targeted mRNA and corresponding protein.
Cite:
Zhdanov V.P.
Slow Relaxation During and After Perturbation of Bistable Kinetics of Gene Expression
European Biophysics Journal with Biophysics Letters. 2019. V.48. N3. P.297–302. DOI: 10.1007/s00249-019-01358-3 WOS Scopus РИНЦ AN PMID OpenAlex
Slow Relaxation During and After Perturbation of Bistable Kinetics of Gene Expression
European Biophysics Journal with Biophysics Letters. 2019. V.48. N3. P.297–302. DOI: 10.1007/s00249-019-01358-3 WOS Scopus РИНЦ AN PMID OpenAlex
Dates:
| Submitted: | Aug 12, 2018 |
| Accepted: | Mar 9, 2019 |
| Published online: | Mar 22, 2019 |
| Published print: | Apr 1, 2019 |
Identifiers:
| Web of science: | WOS:000463833800008 |
| Scopus: | 2-s2.0-85064082036 |
| Elibrary: | 38689097 |
| Chemical Abstracts: | 2019:798230 |
| PMID: | 30903265 |
| OpenAlex: | W2923114352 |