Ultrafine Organic Aerosol Particles Inhaled by Mice at Low Doses Remain in Lungs More than Half an Year | Sciact - CRIS-system of Boreskov Institute of Catalysis

Ultrafine Organic Aerosol Particles Inhaled by Mice at Low Doses Remain in Lungs More than Half an Year Full article

Conference

13th International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds
03-07 Jun 2018 , Prague

Journal

Journal of Labelled Compounds and Radiopharmaceuticals
ISSN: 0362-4803 , E-ISSN: 1099-1344

Output data

Year: 2019, Volume: 62, Number: S11, Pages: 785-793 Pages count : 9 DOI: 10.1002/jlcr.3788

Tags

organic aerosols, low-dose inhalation, polystyrene beads, radiocarbon, accelerator mass-spectrometry, mice

Authors

Parkhomchuk Ekaterina V. ^1,2 , Prokopyeva Elena A. ^1,3 , Gulevich Dayana G. ¹ , Taratayko Anrey I. ^1,4 , Baklanov Anatoly M. ⁵ , Kalinkin Peter N. ^1,2 , Rastigeev Sergey A. ^1,6 , Kuleshov Dmitry V. ¹ , Sashkina Kseniya A. ^1,2 , Parkhomchuk Vasiliy V. ^1,6

Affiliations

1	Novosibirsk State University, Laboratory of Radiocarbon Methods of Analyses, 2 Pirogova st., Novosibirsk 630090, Russia
2	Boreskov Institute of Catalysis SB RAS, 5 Lavrentieva st., Novosibirsk 630090, Russia
3	Federal Research Center of Fundamental and Translational Medicine, 2 Timakov st., Novosibirsk, 630117, Russia
4	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 9 Lavrentieva st., Novosibirsk 630090, Russia
5	Voevodsky Institute of Chemical Kinetics and Combustion SB RAS, 3 Institutskaya st., Novosibirsk 630090, Russia
6	Budker Institute of Nuclear Physics SB RAS, 11 Lavrentieva st., Novosibirsk 630090, Russia

Funding (1)

Federal Agency for Scientific Organizations

0303-2016-0010

Experimental results of the second series of experiments on the penetration of monodisperse polymeric particles, inhaled at low dose by mice, to different organs using direct way of particle registration, based on the ultra‐sensitive accelerator mass‐spectrometer (AMS), are presented. Polystyrene (PS) beads, composed of radiocarbon‐labeled styrene, were produced for testing them as model organic aerosols. Mice inhaled 14C‐PS aerosol of 3·105 ultrafine particles per 1 cm3 for 30 minutes every day during five days. Long‐term investigation showed that PS ultrafine particles have been effectively accumulated in lungs with the maximum content in the fifth day of postexposure, and have also appeared in liver on the fifth day of exposure and in the brain on the thirtieth day of experiments. No particles have been detected in kidneys, spleen and excrements. 35 millions of particles remained in the lungs after half a year of postexposure showing extremely slow removal of such particles from the organ.

Parkhomchuk E.V. , Prokopyeva E.A. , Gulevich D.G. , Taratayko A.I. , Baklanov A.M. , Kalinkin P.N. , Rastigeev S.A. , Kuleshov D.V. , Sashkina K.A. , Parkhomchuk V.V.
Ultrafine Organic Aerosol Particles Inhaled by Mice at Low Doses Remain in Lungs More than Half an Year
Journal of Labelled Compounds and Radiopharmaceuticals. 2019. V.62. NS11. P.785-793. DOI: 10.1002/jlcr.3788 WOS Scopus РИНЦ AN PMID OpenAlex

Submitted:	Mar 28, 2019
Accepted:	Jul 15, 2019
Published online:	Jul 20, 2019
Published print:	Oct 28, 2019

Web of science:	WOS:000484295500001
Scopus:	2-s2.0-85071370547
Elibrary:	41678194
Chemical Abstracts:	2019:1698306
PMID:	31325367
OpenAlex:	W2964103308

DB	Citing
Scopus	5
Web of science	5
Elibrary	6
OpenAlex	6