Air Detoxification with Nanosize TiO2 Aerosol Tested on Mice Full article
| Journal |
Journal of Hazardous Materials
ISSN: 0304-3894 , E-ISSN: 1873-3336 |
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| Output data | Year: 2010, Volume: 173, Number: 1-3, Pages: 40-46 Pages count : 7 DOI: 10.1016/j.jhazmat.2009.08.042 | ||||||||||||
| Tags | Anti-terrorism, Chemiluminescence, CWA, FTIR spectroscopy | ||||||||||||
| Authors |
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| Affiliations |
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Funding (5)
| 1 | Президиум РАН | 27.56 |
| 2 | North Atlantic Treaty Organization | SfP-981461 |
| 3 | International Science and Technology Center | 3305 |
| 4 | Siberian Branch of the Russian Academy of Sciences | 70 |
| 5 | Siberian Branch of the Russian Academy of Sciences | 36 |
Abstract:
A method for fast air purification using high concentration aerosol of TiO(2) nanoparticles is evaluated in a model chemical catastrophe involving toxic vapors of diisopropyl fluorophosphate (DFP). Mice are used as human model in a closed 100 dm(3) chamber. Exposure of mice to 37 ppm of DFP vapor for 15 min resulted in acute poisoning. Spraying TiO(2) aerosol in 2 min after the start of exposure to DFP vapors resulted in quick removal of DFP vapors from the chamber's air. Animals did not show signs of poisoning after the decontamination experiment and exposure to TiO(2) aerosol alone. Reactive oxygen species (ROS) and antioxidant activity (AOA) of mice blood plasma were measured for animals exposed to sound of aerosol generator, DFP vapors, TiO(2) aerosol and DFP vapors+TiO(2) aerosol. Reduced ROS and increased AOA were found for mice exposure to sound, DFP and TiO(2) aerosol. Exposure to DFP and decontamination with TiO(2) nanoparticles resulted in decreased AOA in 48 h following the exposure. The results suggest that application of TiO(2) aerosol is a powerful method of air purification from toxic hydrolysable compounds with moderate health aftermaths and requires further study and optimization.
Cite:
Besov A.S.
, Krivova N.A.
, Vorontsov A.V.
, Zaeva O.B.
, Kozlov D.V.
, Vorozhtsov A.B.
, Parmon V.N.
, Sakovich G.V.
, Komarov V.F.
, Smirniotis P.G.
, Eisenreich N.
Air Detoxification with Nanosize TiO2 Aerosol Tested on Mice
Journal of Hazardous Materials. 2010. V.173. N1-3. P.40-46. DOI: 10.1016/j.jhazmat.2009.08.042 WOS Scopus РИНЦ OpenAlex ANCAN PMID
Air Detoxification with Nanosize TiO2 Aerosol Tested on Mice
Journal of Hazardous Materials. 2010. V.173. N1-3. P.40-46. DOI: 10.1016/j.jhazmat.2009.08.042 WOS Scopus РИНЦ OpenAlex ANCAN PMID
Dates:
| Submitted: | Jun 16, 2009 |
| Accepted: | Aug 10, 2009 |
| Published online: | Aug 18, 2009 |
| Published print: | Jan 15, 2010 |
Identifiers:
| ≡ Web of science: | WOS:000273135600004 |
| ≡ Scopus: | 2-s2.0-71749107902 |
| ≡ Elibrary: | 15335329 |
| ≡ OpenAlex: | W2010966893 |
| ≡ Chemical Abstracts: | 2009:1481563 |
| ≡ Chemical Abstracts (print): | 153:341842 |
| ≡ PMID: | 19765900 |