Synthesis, Crystal Structures, Spectroscopic, and Cytotoxicity Study of Cu(II), Co(II), Ni(II) and Pd(II) Complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione | Sciact - CRIS-system of Boreskov Institute of Catalysis

Synthesis, Crystal Structures, Spectroscopic, and Cytotoxicity Study of Cu(II), Co(II), Ni(II) and Pd(II) Complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione Full article

Journal

Polyhedron
ISSN: 0277-5387

Output data

Year: 2020, Volume: 178, Article number : 114325, Pages count : 7 DOI: 10.1016/j.poly.2019.114325

Tags

Crystal structures; Cytotoxicity; Hep-2; Mononuclear complexes; β-Enaminone

Authors

Eremina Julia A. ^1,2,3 , Lider Elizaveta V. ^1,2 , Sukhikh Taisiya S. ^1,2 , Eltsov Ilia V. ² , Kuratieva Natalia V. ^1,2 , Zakharov Boris A. ^2,4 , Sheludyakova Liliya A. ^1,2 , Klyushova Lyubov S. ^3,7 , Ermakova Ekaterina A. ^1,2 , Dotsenko Victor V. ^5,6

Affiliations

1	Nikolaev Institute of Inorganic Chemistry, SB RAS, 3, Acad. Lavrentiev Ave., Novosibirsk, 630090, Russia
2	Novosibirsk State University, 2, Pirogova Str., Novosibirsk, 630090, Russia
3	Institute of Molecular Biology and Biophysics – Subdivision of FRC FTM, 2/12 Timakova Str., Novosibirsk, 630117, Russia
4	Boreskov Institute of Catalysis SB RAS, 5, Lavrentieva Str., Novosibirsk, 630090, Russia
5	Kuban State University, 149, Stavropol'skaya Str., Krasnodar, 350040, Russia
6	North Caucasus Federal University, Department of Chemistry, 1a, Pushkin Str., Stavropol, 355009, Russia
7	Scientific Institute of Clinical and Experimental Lymphology - Branch of the ICG SB RAS, Novosibirsk, 630060, Russia

Funding (3)

1	Ministry of Science and Higher Education of the Russian Federation	0239-2019-0003
2	Russian Science Foundation	18-73-00294 (АААА-А18-118071090045-2)
3	The Ministry of Education and Science of the Russian Federation	4.5547.2017/БЧ (АААА-А17-117042510372-9)

The coordination compounds of Cu(II), Co(II), Ni(II) and Pd(II) with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione (HL) of the composition [ML2(C2H5OH)2]·nH2O (M = Co (n = 1), Ni (n = 0)) and [ML2] (M = Cu, Pd) have been prepared and investigated by elemental analysis, IR-spectroscopy, NMR spectroscopy, powder X-ray diffraction analysis. Single-crystal X-ray diffraction analysis shows that HL serves as a chelate bidentate ligand coordinated to the metal ion through the N and O atoms forming a six-membered chelate ring. The coordination polyhedron of the metal atoms is a square bipyramid [ML2(C2H5OH)2] or square planar [ML2]. The Cu(II) and Pd(II) complexes stability in solution has been shown by NMR spectroscopy. The results of the cell viability study on Hep2 (human larynx carcinoma) cells demonstrate that the complexes don't exhibit strong cytotoxic effect against Hep-2 cell line compared to cisplatin (IC50 = 9,2 ± 0,5 μM). Palladium(II) complex is the most cytotoxic among all complexes and shows IC50 value of 68,7 ± 5,3 μM. © 2019

Eremina J.A. , Lider E.V. , Sukhikh T.S. , Eltsov I.V. , Kuratieva N.V. , Zakharov B.A. , Sheludyakova L.A. , Klyushova L.S. , Ermakova E.A. , Dotsenko V.V.
Synthesis, Crystal Structures, Spectroscopic, and Cytotoxicity Study of Cu(II), Co(II), Ni(II) and Pd(II) Complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione
Polyhedron. 2020. V.178. 114325 :1-7. DOI: 10.1016/j.poly.2019.114325 WOS Scopus РИНЦ ANCAN OpenAlex

Submitted:	Aug 21, 2019
Accepted:	Dec 19, 2019
Published online:	Dec 23, 2019
Published print:	Mar 1, 2020

Web of science:	WOS:000523754500026
Scopus:	2-s2.0-85077316510
Elibrary:	43219777
Chemical Abstracts:	2020:106344
Chemical Abstracts (print):	172:287143
OpenAlex:	W2998304945

DB	Citing
Scopus	14
Web of science	13
Elibrary	13
OpenAlex	14