Carbon-Mineral Carriers for Active Pharmaceutical Substance | Sciact - CRIS-system of Boreskov Institute of Catalysis

Carbon-Mineral Carriers for Active Pharmaceutical Substance Full article

Conference

2019 Международная мультиконференция по инженерным, компьютерным и информационным наукам
21-27 Oct 2019 , Новосибирск, Томск, Екатеринбург

Source

IEEE 2019 International Multi-Conference on Engineering, Computer and Information Sciences (SIBIRCON)
Compilation, IEEE. 2019. 1012 c. ISBN 978-1-7281-4401-6.

Output data

Year: 2019, Article number : 8958123, Pages count : 4 DOI: 10.1109/SIBIRCON48586.2019.8958123

Tags

carbon-mineral carriers; flow cytometry; porosity; red blood cells; safety

Authors

Maltsev Valery ¹ , Smagin Alexander ² , Rachkovskaya Lubov ² , Rachkovsky Edmond ² , Nimaev Vadim ² , Yastrebova Ekaterina ¹ , Volodin Alexander ³ , Korolev Maxim ² , Vedyagin Alexei ³ , Shurlygina Anna ² , Pivkina Anastasiya ⁴

Affiliations

1	VV Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
2	RICEL - Branch of IC&G SB RAS, Novosibirsk, Russian Federation
3	Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
4	Novosibirsk State University, Novosibirsk, Russian Federation

The paper presents data on the synthesis and study of physical, chemical and biological properties of meso-, and macroporous carbon-mineral carriers based on mechanically strong aluminum oxide ((γ-A1203,) and carbon. Carriers with a carbon content of 7-10%, obtained at temperatures up to 700 °C, have a hydrophilic-hydrophobic nature of the surface and a specific surface area of up to 180 m2/g, and adsorption properties of carriers are estimated for the methylene blue dye up to 19 mg/g, and for the vitamin B12 up to 92 mg/g. Biological properties of carriers were evaluated by their effect on morphological and functional characteristics of red blood cells (RBC), which are the main blood cells and perform mainly transport and buffer functions. The study used the patient's blood before and after hip replacement surgery. Blood after surgery was passed through a glass column with carriers at a rate of 4 ml/min. The parameters of RBC were evaluated by scanning flow cytometry. The obtained results indicate a high informativeness of the method used to determine the parameters of RBC morphology and function. The morphology parameters of RBC include diameter, maximum and minimum thickness of cells, volume and surface area, sphericity index of the cell, spontaneous curvature of the membrane, hemoglobin concentration. The functional parameters include the number of active anion exchangers (band 3 proteins) and the ultimate extensibility of RBC membrane (stiffness to elasticity ratio). The best combination of parameters allows us to select a sample Al2O3@C2-700, obtained using an oxygen-containing organic substance as a carbon source. © 2019 IEEE.

Maltsev V. , Smagin A. , Rachkovskaya L. , Rachkovsky E. , Nimaev V. , Yastrebova E. , Volodin A. , Korolev M. , Vedyagin A. , Shurlygina A. , Pivkina A.
Carbon-Mineral Carriers for Active Pharmaceutical Substance
In compilation IEEE 2019 International Multi-Conference on Engineering, Computer and Information Sciences (SIBIRCON). – IEEE., 2019. – C.0305-0308. – ISBN 978-1-7281-4401-6. DOI: 10.1109/SIBIRCON48586.2019.8958123 Scopus РИНЦ OpenAlex

Published print:

Oct 1, 2019

Scopus:	2-s2.0-85079039642
Elibrary:	43251341
OpenAlex:	W3000388797

DB	Citing
Scopus	2
Elibrary	2
OpenAlex	2