Competing Interactions of Fatty Acids and Monoglycerides Trigger Synergistic Phospholipid Membrane Remodeling | Sciact - CRIS-system of Boreskov Institute of Catalysis

Competing Interactions of Fatty Acids and Monoglycerides Trigger Synergistic Phospholipid Membrane Remodeling Full article

Journal

Journal of Physical Chemistry Letters
ISSN: 1948-7185

Output data

Year: 2020, Volume: 11, Number: 13, Pages: 4951-4957 Pages count : 7 DOI: 10.1021/acs.jpclett.0c01138

Tags

supported lipid bilayer; fatty acid; monoglyceride; membrane morphological changes; quartz crystal microbalance; fluorescence microscopy

Authors

Yoon Bo Kyeong ^1,2 , Park Soohyun ¹ , Ma Gamaliel J. ¹ , Kolahdouzan Kavoos ^1,3 , Zhdanov Vladimir P. ⁴ , Jackman Joshua A. ² , Cho Nam-Joon ¹

Affiliations

1	School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Drive 637553, Singapore
2	School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea
3	Department of Chemistry, Pomona College, 645 North College Avenue, Claremont, California 91711, United States
4	Boreskov Institute of Catalysis, Russian Academy of Sciences, Novosibirsk 630090, Russia

Funding (3)

1	National Research Foundation of Singapore	NRF2015NRF-POC0001-019
2	National Research Foundation of Korea	2019H1D3A1A01070318
3	National Research Foundation of Korea	2020R1C1C1004385

Using quartz crystal microbalance-dissipation and time-lapse fluorescence microscopy, we demonstrate that adding mixtures of lauric acid (LA) and glycerol monolaurate (GML), two of the most biologically active antimicrobial fatty acids and monoglycerides, to a supported lipid bilayer triggers concurrent tubule and bud formation, which unexpectedly results in synergistic phospholipid membrane remodeling that far exceeds the effects of GML or LA alone. Together, GML and LA drive pearling instability, dynamic transformation of buds into tubules and vice versa, and extensive membrane lysis. The most pronounced effects occurred with equimolar concentrations of GML and LA, highlighting that synergistic membrane disruption arises from competition for the lipid supply to buds and tubules and an inability to relieve membrane strains. These findings offer a conceptually new model to explain how fatty acid and monoglyceride interactions can trigger phospholipid membrane remodeling events relevant to various biophysical and biological systems.

Yoon B.K. , Park S. , Ma G.J. , Kolahdouzan K. , Zhdanov V.P. , Jackman J.A. , Cho N-J.
Competing Interactions of Fatty Acids and Monoglycerides Trigger Synergistic Phospholipid Membrane Remodeling
Journal of Physical Chemistry Letters. 2020. V.11. N13. P.4951-4957. DOI: 10.1021/acs.jpclett.0c01138 WOS Scopus РИНЦ ANCAN PMID OpenAlex

Submitted:	Apr 13, 2020
Accepted:	Jun 1, 2020
Published online:	Jun 10, 2020
Published print:	Jul 2, 2020

Web of science:	WOS:000547468400004
Scopus:	2-s2.0-85087529295
Elibrary:	45491184
Chemical Abstracts:	2020:1048157
Chemical Abstracts (print):	173:856281
PMID:	32478524
OpenAlex:	W3030798113

DB	Citing
Scopus	26
Web of science	23
Elibrary	19
OpenAlex	28