Quantifying the Effects of Quadrupolar Sinks via 15N Relaxation Dynamics in Metronidazoles Hyperpolarized via SABRE-SHEATH | Sciact - CRIS-system of Boreskov Institute of Catalysis

Quantifying the Effects of Quadrupolar Sinks via 15N Relaxation Dynamics in Metronidazoles Hyperpolarized via SABRE-SHEATH Full article

Journal

Chemical Communications
ISSN: 1359-7345 , E-ISSN: 1364-548X

Output data

Year: 2020, Volume: 56, Number: 14, Pages: 9098–9101 Pages count : 4 DOI: 10.1039/d0cc03994b

Tags

REVERSIBLE EXCHANGE; SIGNAL AMPLIFICATION; CATALYSTS; MRI

Authors

Birchall Jonathan R. ¹ , Kabir Mohammad S.H. ¹ , Salnikov Oleg G. ^2,3,4 , Chukanov Nikita V. ^2,3 , Svyatova Alexandra ^2,3 , Kovtunov Kirill V. ^2,3 , Koptyug Igor V. ^2,3 , Gelovani Juri G. ^1,5 , Goodson Boyd M. ⁶ , Pham Wellington ⁷ , Chekmenev Eduard Y. ^1,8

Affiliations

1	Department of Chemistry, Integrative Biosciences (Ibio), Wayne State University, Karmanos Cancer Institute (KCI), Detroit, Michigan 48202, USA
2	International Tomography Center SB RAS, 3A Institutskaya St., Novosibirsk 630090, Russia, Leninskiy Prospekt 14, Moscow, Russia
3	Novosibirsk State University, 2 Pirogova St., Novosibirsk 630090, Russia
4	Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., Novosibirsk 630090, Russia
5	United Arab Emirates University, Al Ain, United Arab Emirates
6	Department of Chemistry and Biochemistry and Materials Technology Center, Southern Illinois University, Carbondale, Illinois 62901, USA
7	Vanderbilt University Institute of Imaging Science (VUIIS), Department of Radiology, Vanderbilt University Medical Center (VUMC), Department of Biomedical Engineering, Vanderbilt University, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee 37232-2310, USA
8	Russian Academy of Sciences

Funding (11)

1	National Science Foundation	CHE-1904780
2	National Science Foundation	CHE-1905341
3	National Institutes of Health	1R21CA220137
4	United States Department of Defense	W81XWH-12-1-0159/BC112431
5	United States Department of Defense	W81XWH-15-1-0271
6	United States Department of Defense	W81XWH-15-1-0272
7	Russian Foundation for Basic Research	19-33-60045
8	Russian Foundation for Basic Research	18-43-543023 (АААА-А18-118060990008-2)
9	Federal Agency for Scientific Organizations	0333-2016-0002 (АААА-А16-116121510087-5)
10	Russian Foundation for Basic Research	19-29-10003 (АААА-А19-119100890052-8)
11	Russian Foundation for Basic Research	17-54-33037

15 N spin–lattice relaxation dynamics in metronidazole-15N3 and metronidazole-15N2 isotopologues are studied for rational design of 15N-enriched biomolecules for signal amplification by reversible exchange in microtesla fields. 15N relaxation dynamics mapping reveals the deleterious effects of interactions with the polarization transfer catalyst and a quadrupolar 14N nucleus within the spin-relayed 15N–15N network.

Birchall J.R. , Kabir M.S.H. , Salnikov O.G. , Chukanov N.V. , Svyatova A. , Kovtunov K.V. , Koptyug I.V. , Gelovani J.G. , Goodson B.M. , Pham W. , Chekmenev E.Y.
Quantifying the Effects of Quadrupolar Sinks via 15N Relaxation Dynamics in Metronidazoles Hyperpolarized via SABRE-SHEATH
Chemical Communications. 2020. V.56. N14. P.9098–9101. DOI: 10.1039/d0cc03994b WOS Scopus РИНЦ ANCAN OpenAlex

Submitted:	May 8, 2020
Published online:	Jun 14, 2020
Accepted:	Jun 30, 2020
Published print:	Aug 18, 2020

Web of science:	WOS:000558045700033
Scopus:	2-s2.0-85089359035
Elibrary:	45367646
Chemical Abstracts:	2020:1384802
Chemical Abstracts (print):	174:357864
OpenAlex:	W3042889060

DB	Citing
Scopus	32
Web of science	31
Elibrary	30
OpenAlex	38