Реферат: The studies of the biological and biomimetic objects are important not only for fundamental science but also for the design of drugs and materials. The crystal structure of a hydrate of the sodium salt of guanine (2Na+·C5H3N5O2-·7H2O) [1] was studied using single crystal X-ray diffraction and Raman spectroscopy up to ~2.5 GPa, after what the structure collapsed and the diffraction pattern disappeared. On increasing pressure, the distances between the double walls of the slit channels formed by the guanine moieties became more equal, the longer one shortening and the shorter one expanding. The topology of the Na+ - water intra-channel infinite clusters was preserved, although these clusters got distorted on compression. Among several types of the NH…O and OH…O hydrogen bonds, only two practically did not change with increasing pressure, namely the OH…O and the NH…O bonds connecting the guanine walls with the intra-channel water molecules. A possible relation to the interactions in the ion channels with the walls formed by the guanine species in biological systems is discussed.

Библиографическая ссылка: Gaydamaka A. , Arkhipov S. , Zakharov B. , Seryotkin Y. , Boldyreva E.
Effect of Pressure on Slit Channels in Hydrate of Sodium Salt of Guanine: A Link to Nucleobase Intermolecular Interactions
Acta Crystallographica Section A: Foundations and Advances (предыдущее название Acta Crystallographica Section A: Foundations of Crystallography). 2019. V.75. MS17-P04 :1-1. DOI: 10.1107/S2053273319092532 WOS РИНЦ OpenAlex

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18 авг. 2019 г.

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Web of science:	WOS:000552083100303
РИНЦ:	47691605
OpenAlex:	W3038408146

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