Virions and Respiratory Droplets in Air: Diffusion, Drift, and Contact with the Epithelium | Sciact - CRIS-система Института катализа

Virions and Respiratory Droplets in Air: Diffusion, Drift, and Contact with the Epithelium Научная публикация

Журнал

Biosystems
ISSN: 0303-2647 , E-ISSN: 1872-8324

Вых. Данные

Год: 2020, Том: 198, Номер статьи : 104241, Страниц : 11 DOI: 10.1016/j.biosystems.2020.104241

Ключевые слова

Viruses; Epithelium; Respiratory droplets; Diffusion and drift; Convection; Evaporation

Авторы

Zhdanov Vladimir P. ^1,2 , Kasemo Bengt ¹

Организации

1	Sections of Nano and Biological Physics and Chemical Physics, Department of Physics, Chalmers University of Technology, Göteborg, Sweden
2	Boreskov Institute of Catalysis, Russian Academy of Sciences, Novosibirsk, Russia

Some infections, including e.g. influenza and currently active COVID 19, may be transmitted via air during sneezing, coughing, and talking. This pathway occurs via diffusion and gravity-induced drift of single virions and respiratory droplets consisting primarily of water, including small fraction of nonvolatile matter, and containing virions. These processes are accompanied by water evaporation resulting in reduction of the droplet size. The manifold of information concerning these steps is presented in textbooks and articles not related to virology and the focus is there frequently on biologically irrelevant conditions and/or droplet sizes. In this brief review, we systematically describe the behaviour of virions and virion-carrying droplets in air with emphasis on various regimes of diffusion, drift, and evaporation, and estimate the rates of all these steps under virologically relevant conditions. In addition, we discuss the kinetic aspects of the first steps of infection after attachment of virions or virion-carrying droplets to the epithelium, i.e., virion diffusion in the mucus and periciliary layers, penetration into the cells, and the early stage of replication. The presentation is oriented to virologists who are interested in the corresponding physics and to physicists who are in interested in application of the physics to virology.

Zhdanov V.P. , Kasemo B.
Virions and Respiratory Droplets in Air: Diffusion, Drift, and Contact with the Epithelium

Biosystems. 2020. V.198. 104241 :1-11. DOI: 10.1016/j.biosystems.2020.104241 WOS Scopus РИНЦ CAPlus PMID OpenAlex

Полный текст от издателя

Поступила в редакцию:	12 июл. 2020 г.
Принята к публикации:	2 сент. 2020 г.
Опубликована online:	5 сент. 2020 г.
Опубликована в печати:	1 дек. 2020 г.

Web of science:	WOS:000595260100022
Scopus:	2-s2.0-85090992485
РИНЦ:	45289429
Chemical Abstracts:	2020:1863917
PMID (PubMed):	32896576
OpenAlex:	W3083228331

БД	Цитирований
Scopus	8
Web of science	8
РИНЦ	7
OpenAlex	11