Blood Serum and Erythrocyte Lipidomic Profiling Revealed Diagnostic Biomarkers in Patients with Early Stages of CRC and Adenomatous Polyps | Sciact - CRIS-system of Boreskov Institute of Catalysis

Blood Serum and Erythrocyte Lipidomic Profiling Revealed Diagnostic Biomarkers in Patients with Early Stages of CRC and Adenomatous Polyps Conference Abstracts

Conference

28th United European Gastroenterology Week Virtual 2020
11-13 Oct 2020 , Online

Journal

United European Gastroenterology Journal
ISSN: 2050-6406 , E-ISSN: 2050-6414

Output data

Year: 2020, Volume: 8, Number: 8_suppl, Pages: 527 Pages count : 1 DOI: 10.1177/2050640620927345

Tags

COLORECTAL CANCER, FATTY ACIDS, EARLY STAGES

Authors

Kruchinina M.V. ¹ , Gromov A.A. ¹ , Kruchinin V.N. ² , Shashkov M.V. ³ , Sokolova A.S. ⁴ , Shestov A.A. ⁵

Affiliations

1	Research Institute of Internal and Preventive Medicine, Branch of the Institute of Cytology & Genetics, Siberian Branch of the Russian Academy of Sciences
2	Rzhanov Institute of Semiconductor Physics, Siberian Branch of the Russian Academy of Sciences
3	Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences
4	Vorozhtzov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science, 9, Academician Lavrentiev Ave., Novosibirsk, 630090
5	Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States

Objective: A) To investigate if discriminant lipidomics could be used as a potential diagnostic tool for early stages of colorectal cancer (esCRC) and precancerous condition adenomatous polyps (AP). B) to create a list of fatty acids (FAs) in the erythrocyte membranes (Er) and in blood serum (BS), the levels of which can be used as biomarkers of esCRC and AP. C) To investigate the accuracy of machine learning methods and different FAs sets to classify esCRC and AP patients from healthy individuals. Aims & Methods: A total of 65 CRC patients with disease stages 1 and 2, as well as 25 patients with adenomatous polyps, and 35 conditionally healthy persons were included. The analysis of the Er and BS fatty acids (FAs) composition has been carried out using a gas chromatography-mass spectrometry (GC/MS) system based on the Agilent 7000B Triple Quadrupole (USA). Measured sets of FAs and two machine learning methods (support vector machine and random forest) were used to classify esCRC and AP patients from healthy participants as well as esCRC patients from AP. Results: We have determined the levels of >30 FAs and their ratios in BS and Er membranes for the proband groups...

Kruchinina M.V. , Gromov A.A. , Kruchinin V.N. , Shashkov M.V. , Sokolova A.S. , Shestov A.A.
Blood Serum and Erythrocyte Lipidomic Profiling Revealed Diagnostic Biomarkers in Patients with Early Stages of CRC and Adenomatous Polyps

United European Gastroenterology Journal. 2020. V.8. N8_suppl. P.527. DOI: 10.1177/2050640620927345 Scopus РИНЦ OpenAlex

Full text from publisher

Published print:	Oct 1, 2020
Published online:	Oct 10, 2020

Scopus:	2-s2.0-85092753863
Elibrary:	44090671
OpenAlex:	W3212599147

DB	Citing
Scopus	4
OpenAlex	10