15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields | Sciact - CRIS-system of Boreskov Institute of Catalysis

15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields Full article

Journal

Angewandte Chemie - International Edition
ISSN: 1433-7851 , E-ISSN: 1521-3773

Output data

Year: 2021, Volume: 60, Number: 5, Pages: 2406–2413 Pages count : 8 DOI: 10.1002/anie.202011698

Tags

hyperpolarization; nimorazole; parahydrogen; radiosensitization; SABRE-SHEATH

Authors

Salnikov Oleg G. ^1,2,3 , Chukanov Nikita V. ^2,3 , Svyatova Alexandra ^2,3 , Trofimov Ivan A. ^2,3 , Kabir Mohammad S.H. ⁴ , Gelovani Juri G. ^4,5 , Kovtunov Kirill V. ^2,3 , Koptyug Igor V. ^2,3 , Chekmenev Eduard Y. ^4,6

Affiliations

1	Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., 630090 Novosibirsk (Russia)
2	International Tomography Center SB RAS, 3A Institutskaya St., 630090 Novosibirsk (Russia)
3	Department of Natural Sciences, Novosibirsk State University, 2 Pirogova St., 630090 Novosibirsk (Russia)
4	Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, MI 48202 (USA)
5	College of Medicine and Health Sciences, United Arab Emirates University, Al Ain (United Arab Emirates)
6	Russian Academy of Sciences (RAS), 14 Leninskiy Prospekt, 119991 Moscow (Russia)

Funding (7)

1	Russian Foundation for Basic Research	19-33-60045
2	National Science Foundation	CHE-1904780
3	National Institutes of Health	1R21CA220137
4	Russian Foundation for Basic Research	17-54-33037
5	Russian Foundation for Basic Research	18-33-20019 (АААА-А18-118101090008-1)
6	Russian Foundation for Basic Research	19-53-12013 (АААА-А19-119040990042-7)
7	Federal Agency for Scientific Organizations	0333-2016-0002 (АААА-А16-116121510087-5)

Nimorazole belongs to the imidazole‐based family of antibiotics to fight against anaerobic bacteria. Moreover, nimorazole is now in Phase 3 clinical trial in Europe for potential use as a hypoxia radiosensitizer for treatment of head and neck cancers. We envision the use of [15N3]nimorazole as a theragnostic hypoxia contrast agent that can be potentially deployed in the next‐generation MRI‐LINAC systems. Herein, we report the first steps to create long‐lasting (for tens of minutes) hyperpolarized state on three 15N sites of [15N3]nimorazole with T1 of up to ca. 6 minutes. The nuclear spin polarization was boosted by ca. 67000‐fold at 1.4 T (corresponding to P15N of 3.2 %) by 15N−15N spin‐relayed SABRE‐SHEATH hyperpolarization technique, relying on simultaneous exchange of [15N3]nimorazole and parahydrogen on polarization transfer Ir‐IMes catalyst. The presented results pave the way to efficient spin‐relayed SABRE‐SHEATH hyperpolarization of a wide range of imidazole‐based antibiotics and chemotherapeutics.

Salnikov O.G. , Chukanov N.V. , Svyatova A. , Trofimov I.A. , Kabir M.S.H. , Gelovani J.G. , Kovtunov K.V. , Koptyug I.V. , Chekmenev E.Y.
15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields
Angewandte Chemie - International Edition. 2021. V.60. N5. P.2406–2413. DOI: 10.1002/anie.202011698 WOS Scopus РИНЦ AN PMID OpenAlex

Salnikov O.G. , Chukanov N.V. , Svyatova A. , Trofimov I.A. , Kabir M.S.H. , Gelovani J.G. , Kovtunov K.V. , Koptyug I.V. , Chekmenev E.Y.
15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields
Angewandte Chemie (German edition). 2021. V.133. N5. P.2436–2443. DOI: 10.1002/ange.202011698 РИНЦ OpenAlex

Submitted:	Aug 26, 2020
Published online:	Oct 15, 2020
Published print:	Feb 1, 2021

Web of science:	WOS:000594405000001
Scopus:	2-s2.0-85097006619
Elibrary:	45108428
Chemical Abstracts:	2020:2484231
PMID:	33063407
OpenAlex:	W3092877373

DB	Citing
Web of science	34
Scopus	35
Elibrary	36
OpenAlex	42