Low‐Flammable Parahydrogen‐Polarized MRI Contrast Agents | Sciact - CRIS-system of Boreskov Institute of Catalysis

Low‐Flammable Parahydrogen‐Polarized MRI Contrast Agents Full article

Journal

Chemistry - A European Journal
ISSN: 0947-6539 , E-ISSN: 1521-3765

Output data

Year: 2020, Volume: 27, Number: 8, Pages: 2774-2781 Pages count : 8 DOI: 10.1002/chem.202004168

Tags

flammability; fluorine; hyperpolarization; inhalable anesthetics; parahydrogen

Authors

Joalland Baptiste ¹ , Ariyasingha Nuwandi M. ¹ , Younes Hassan R. ¹ , Nantogma Shiraz ¹ , Salnikov Oleg G. ^2,3,4 , Chukanov Nikita V. ^2,3 , Kovtunov Kirill V. ^2,3 , Koptyug Igor V. ^2,3 , Gelovani Juri G. ^1,5 , Chekmenev Eduard Y. ^1,6

Affiliations

1	Department of Chemistry, Integrative Biosciences (Ibio) Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan 48202 (USA)
2	International Tomography Center SB RAS, Institutskaya St. 3A, 630090 Novosibirsk (Russia)
3	Department of Natural Sciences, Novosibirsk State University, Pirogova St. 2, 630090 Novosibirsk (Russia)
4	Boreskov Institute of Catalysis SB RAS, Acad. Lavrentiev Prospekt 5, 630090 Novosibirsk (Russia)
5	United Arab Emirates University, Al Ain (United Arab Emirates)
6	Russian Academy of Sciences, Leninskiy Prospekt 14, Moscow, 119991 (Russia)

Funding (9)

1	National Science Foundation	CHE-1904780
2	United States Department of Defense	W81XWH-15-1-0271
3	National Institutes of Health	1R21HL154032-01
4	Russian Foundation for Basic Research	17-54-33037
5	Russian Foundation for Basic Research	19-53-12013 (АААА-А19-119040990042-7)
6	Russian Foundation for Basic Research	19-29-10003 (АААА-А19-119100890052-8)
7	Russian Foundation for Basic Research	19-33-60045
8	Federal Agency for Scientific Organizations	0333-2016-0002 (АААА-А16-116121510087-5)
9	United States Department of Defense	W81XWH-20-1-0576

Many MRI contrast agents formed with the parahydrogen‐induced polarization (PHIP) technique exhibit biocompatible profiles. In the context of respiratory imaging with inhalable molecular contrast agents, the development of nonflammable contrast agents would nonetheless be highly beneficial for the biomedical translation of this sensitive, high‐throughput and affordable hyperpolarization technique. To this end, we assess the hydrogenation kinetics, the polarization levels and the lifetimes of PHIP hyperpolarized products (acids, ethers and esters) at various degrees of fluorine substitution. The results highlight important trends as a function of molecular structure that are instrumental for the design of new, safe contrast agents for in vivo imaging applications of the PHIP technique, with an emphasis on the highly volatile group of ethers used as inhalable anesthetics.

Joalland B. , Ariyasingha N.M. , Younes H.R. , Nantogma S. , Salnikov O.G. , Chukanov N.V. , Kovtunov K.V. , Koptyug I.V. , Gelovani J.G. , Chekmenev E.Y.
Low‐Flammable Parahydrogen‐Polarized MRI Contrast Agents
Chemistry - A European Journal. 2020. V.27. N8. P.2774-2781. DOI: 10.1002/chem.202004168 WOS Scopus РИНЦ AN PMID OpenAlex

Submitted:	Sep 13, 2020
Accepted:	Oct 28, 2020
Published online:	Jan 7, 2021
Published print:	Feb 5, 2021

Web of science:	WOS:000614897200026
Scopus:	2-s2.0-85097366415
Elibrary:	45091508
Chemical Abstracts:	2021:84025
PMID:	33112442
OpenAlex:	W3096159834

DB	Citing
Web of science	8
Elibrary	12
Scopus	10
OpenAlex	12