Kinetic Aspects of Virus Targeting by Nanoparticles in vivo Full article
| Journal |
Journal of Biological Physics
ISSN: 0092-0606 , E-ISSN: 1573-0689 |
||||
|---|---|---|---|---|---|
| Output data | Year: 2021, Volume: 47, Number: 2, Pages: 95-101 Pages count : 7 DOI: 10.1007/s10867-021-09570-z | ||||
| Tags | Nanoparticles; Viral infection; Inhibition; Association; Kinetic model | ||||
| Authors |
|
||||
| Affiliations |
|
Funding (2)
| 1 | Ministry of Science and Higher Education of the Russian Federation | 0239-2021-0009 |
| 2 | Chalmers University of Technology |
Abstract:
One of the suggested ways of the use of nanoparticles in virology implies their association with and subsequent deactivation of virions. The conditions determining the efficiency of this approach in vivo are now not clear. Herein, I propose the first kinetic model describing the corresponding processes and clarifying these conditions. My analysis indicates that nanoparticles can decrease concentration of infected cells by a factor of one order of magnitude, but this decrease itself (without feedback of the immune system) is insufficient for full eradication of infection. It can, however, induce delay in the progress of infection, and this delay can help to form sufficient feedback of the immune system.
Cite:
Zhdanov V.P.
Kinetic Aspects of Virus Targeting by Nanoparticles in vivo
Journal of Biological Physics. 2021.
V.47. N2. P.95-101. DOI: 10.1007/s10867-021-09570-z
WOS
Scopus
РИНЦ
PMID
OpenAlex
Kinetic Aspects of Virus Targeting by Nanoparticles in vivo
Journal of Biological Physics. 2021.
V.47. N2. P.95-101. DOI: 10.1007/s10867-021-09570-z
WOS
Scopus
РИНЦ
PMID
OpenAlex
Files:
Full text from publisher
Dates:
| Submitted: | Mar 29, 2021 |
| Accepted: | Apr 26, 2021 |
| Published print: | Jun 2, 2021 |
| Published online: | Jun 2, 2021 |
Identifiers:
| Web of science: | WOS:000657183300001 |
| Scopus: | 2-s2.0-85107414730 |
| Elibrary: | 46817070 |
| PMID: | 34080098 |
| OpenAlex: | W3165390432 |