Radiochemotherapy-Induced Changes in Brain Extracellular Matrix are Associated with Tumour Development in Mouse Recurrent Glioblastoma Model | Sciact - CRIS-system of Boreskov Institute of Catalysis

Radiochemotherapy-Induced Changes in Brain Extracellular Matrix are Associated with Tumour Development in Mouse Recurrent Glioblastoma Model Conference Abstracts

Conference

ESMO 22nd World Congress on Gastrointestinal Cancer
01-04 Jul 2020 , Lugano

Journal

Annals of Oncology
ISSN: 0923-7534 , E-ISSN: 1569-8041

Output data

Year: 2020, Volume: 31, Number: S4, Article number : 6MO, Pages count : 2 DOI: 10.1016/j.annonc.2020.08.159

Authors

Tsidulko A. ¹ , Suhovskih A. ¹ , Kolpakova M. ² , Politko M. ¹ , Kazanskaya G. ³ , Volkov A. ³ , Pashkovskaya O. ⁴ , Kuper K. ⁵ , Shevelev O. ⁶ , Zavjalov E. ⁶ , Aidagulova S. ⁷ , Grigorieva E. ¹

Affiliations

1	Laboratory of Glycobiology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russian Federation
2	Institute of Medicine and Psychology, Novosibirsk State University, Novosibirsk, Russian Federation
3	Department of Pathomorphology, Meshalkin Siberian Federal Biomedical Research Center, Novosibirsk, Russian Federation
4	Department of Radiotherapy, Meshalkin Siberian Federal Biomedical Research Center, Novosibirsk, Russian Federation
5	Synchrotron processes laboratory, Institute of Nuclear Physics SB RAS
6	Laboratory Animal Genetic Resources Center, Institute of Cytology and Genetics SB RAS
7	Central Research Laboratory of Pathomorphology, Novosibirsk State Medical University

Despite intensive treatment, most of patients with glioblastoma (GBM) develop a relapse in 6 months after the first surgery, but the mechanisms of the disease recurrence are not well understood. Insufficient efficiency of the used adjuvant radiochemotherapy might be related to its side-effects on the normal surrounding brain tissue, resulting in the formation of a microenvironmental niche for recurrent tumour growth. Here, we studied the functional effects of therapy on the normal brain extracellular matrix (ECM) and tumour growth in mouse GBM relapse models.

Tsidulko A. , Suhovskih A. , Kolpakova M. , Politko M. , Kazanskaya G. , Volkov A. , Pashkovskaya O. , Kuper K. , Shevelev O. , Zavjalov E. , Aidagulova S. , Grigorieva E.
Radiochemotherapy-Induced Changes in Brain Extracellular Matrix are Associated with Tumour Development in Mouse Recurrent Glioblastoma Model
Annals of Oncology. 2020. V.31. NS4. 6MO :1-2. DOI: 10.1016/j.annonc.2020.08.159 WOS OpenAlex

Published print:	Sep 22, 2020
Published online:	Sep 22, 2020

Web of science:	WOS:000573469100007
OpenAlex:	W3088716502

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