Unraveling How Multivalency Triggers Shape Deformation of Sub-100 nm Lipid Vesicles | Sciact - CRIS-system of Boreskov Institute of Catalysis

Unraveling How Multivalency Triggers Shape Deformation of Sub-100 nm Lipid Vesicles Full article

Journal

Journal of Physical Chemistry Letters
ISSN: 1948-7185

Output data

Year: 2021, Volume: 12, Number: 28, Pages: 6722-6729 Pages count : 8 DOI: 10.1021/acs.jpclett.1c01510

Tags

Nutrition, Vesicles, Deformation, Surface plasmon resonance, Organic compounds

Authors

Park Hyeonjin ^1,2 , Sut Tun Naw ^1,2 , Yoon Bo Kyeong ¹ , Zhdanov Vladimir P. ³ , Cho Nam-Joon ² , Jackman Joshua A. ¹

Affiliations

1	School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea
2	School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Drive 637553, Singapore
3	Boreskov Institute of Catalysis, Russian Academy of Sciences,Novosibirsk 630090, Russia

Multivalent ligand–receptor interactions are critical to the function of membrane-enveloped biological and biomimetic nanoparticles, yet resulting nanoparticle shape changes are rarely investigated. Using the localized surface plasmon resonance (LSPR) sensing technique, we tracked the attachment of biotinylated, sub-100 nm lipid vesicles to a streptavidin-functionalized supported lipid bilayer (SLB) and developed an analytical model to extract quantitative details about the vesicle–SLB contact region. The experimental results were supported by theoretical analyses of biotin–streptavidin complex formation and corresponding structural and energetic aspects of vesicle deformation. Our findings reveal how varying the surface densities of streptavidin receptors in the SLB and biotin ligands in the vesicles affects the extent of nanometer-scale vesicle deformation. We also identify conditions, i.e., a critical ligand density, at which appreciable vesicle deformation began, which provides insight into how the membrane bending energy partially counterposes the multivalent binding interaction energy. These findings are generalizable to various multivalent ligand–receptor systems.

Park H. , Sut T.N. , Yoon B.K. , Zhdanov V.P. , Cho N-J. , Jackman J.A.
Unraveling How Multivalency Triggers Shape Deformation of Sub-100 nm Lipid Vesicles
Journal of Physical Chemistry Letters. 2021. V.12. N28. P.6722-6729. DOI: 10.1021/acs.jpclett.1c01510 WOS Scopus РИНЦ AN PMID OpenAlex

Submitted:	May 11, 2021
Accepted:	Jul 12, 2021
Published online:	Jul 15, 2021
Published print:	Jul 22, 2021

Web of science:	WOS:000677581400036
Scopus:	2-s2.0-85111506248
Elibrary:	46939957
Chemical Abstracts:	2021:1539088
PMID:	34263601
OpenAlex:	W3182305707

DB	Citing
Web of science	11
Scopus	11
Elibrary	7
OpenAlex	13