Combined Use of Findings of Levels of Fatty Acids in Erythrocyte Membranes and Blood Serum as Well as Electric, Viscoelastic Parameters of Erythrocytes Increases Accuracy of Diagnosis of pre-Cancer and Early Colorectal Cancer | Sciact - CRIS-system of Boreskov Institute of Catalysis

Combined Use of Findings of Levels of Fatty Acids in Erythrocyte Membranes and Blood Serum as Well as Electric, Viscoelastic Parameters of Erythrocytes Increases Accuracy of Diagnosis of pre-Cancer and Early Colorectal Cancer Conference Abstracts

Conference

29th United European Gastroenterology Week Virtual 2021
03-05 Oct 2021 , Vienna

Journal

United European Gastroenterology Journal
ISSN: 2050-6406 , E-ISSN: 2050-6414

Output data

Year: 2021, Volume: 9, Number: S8, Article number : P0552, Pages count : 1

Authors

Kruchinina M.V. ^1,2 , Gromov A.A. ¹ , Kruchinin V.N. ³ , Shashkov M.V. ⁴ , Sokolova A.S. ⁵ , Generalov V.M. ⁶ , Yakovina I.N. ⁷ , Shestov A.A. ⁸

Affiliations

1	1 Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology&Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
2	Novosibirsk State Medical University, Novosibirsk, Russia
3	Rzhanov Institute of Semiconductor Physics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
4	Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
5	Vorozhtsov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
6	Federal Budgetary Research Institution «State Research Center of Virology and Biotechnology «Vector», Federal Service for Surveillance on Consumer Rights Protection and Human Well-being, Novosibirsk, Koltsovo, Russia
7	Novosibirsk State Technical University, Novosibirsk, Russia
8	Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States

This study aims to reveal the ways of complex use of findings of levels of fatty acids (FA) of erythrocyte (Er) membranes and blood serum (BS) as well as electric, viscoelastic parameters of Er in diagnosis of pre-cancer and early stages of CRC.sis of pre-cancer and early stages of CRC. 65 patients with CRC (1-2 stages; 63.2+9.4 years), 25 patients with adenomatous polyps (AP), 35 relatively healthy subjects were included into the study. Studies of composition of Er FA and BS were conducted using the GC/MS Agilent 7000B (USA) systems. Studies of electric, viscoelastic parameters of Er were conducted using the method of dielectrophoresis within the frequency range of 0.5х104-106 and application of electrooptic system of cell detection. The SHAP charts were used to build the combined models; the charts demonstrate the importance of the use of the features applied in the models or the degree of impact of certain predictors on the target variable [3]. https://onlinelibrary.wiley.com/doi/epdf/10.1002/ueg2.12144

Kruchinina M.V. , Gromov A.A. , Kruchinin V.N. , Shashkov M.V. , Sokolova A.S. , Generalov V.M. , Yakovina I.N. , Shestov A.A.
Combined Use of Findings of Levels of Fatty Acids in Erythrocyte Membranes and Blood Serum as Well as Electric, Viscoelastic Parameters of Erythrocytes Increases Accuracy of Diagnosis of pre-Cancer and Early Colorectal Cancer
United European Gastroenterology Journal. 2021. V.9. NS8. P0552 :1-1. РИНЦ

Published online:

Oct 2, 2021

Elibrary:

46611012

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