Activated Carbon for Drug Delivery from Composite Biomaterials: The Effect of Grinding on Sirolimus Binding and Release | Sciact - CRIS-system of Boreskov Institute of Catalysis

Activated Carbon for Drug Delivery from Composite Biomaterials: The Effect of Grinding on Sirolimus Binding and Release Full article

Journal

Pharmaceutics
ISSN: 1999-4923

Output data

Year: 2022, Volume: 14, Number: 7, Article number : 1386, Pages count : 15 DOI: 10.3390/pharmaceutics14071386

Tags

activated carbon; drug delivery; controlled release; electrospinning; sirolimus

Authors

Nazarkina Zhanna K. ¹ , Savostyanova Tatyana A. ¹ , Chelobanov Boris P. ¹ , Romanova Irina V. ¹ , Simonov Pavel A. ² , Kvon Ren I. ³ , Karpenko Andrey A. ⁴ , Laktionov Pavel P. ^1,4

Affiliations

1	Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia
2	Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia
3	Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia
4	Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, 630055 Novosibirsk, Russia

Funding (2)

1	Ministry of Science and Higher Education of the Russian Federation	075-00404-21-00 (121031300042-1)
2	Ministry of Health of the Russian Federation	056-00125-21-00 AVRB-2021-0001 (121032300337-5)

Activated carbon (AC) could be potentially useful as a drug carrier in fiber polymer scaffolds destined for prolonged drug delivery. To be introduced, AC must be ground into smaller-sized particles to be introduced in scaffolds, as most biocompatible scaffolds consist of fibers with a diameter of less than 1 µm. In this study, the adsorption of sirolimus (SRL) from phosphate-buffered saline (PBS) solution and blood plasma (BP) onto AC of AX-21 type, as well as the release of SRL from AC depending on its fragmentation, were studied. Two-stage grinding of the AC, first with a ball mill, and then with a bead mill, was performed. Grinding with a bead mill was performed either in water or in polyvinylpyrrolidone to prevent aggregation of AC particles. Dynamic light scattering and scanning electron microscopy (SEM) demonstrated that the size of the particles obtained after grinding with a ball mill was 100–10,000 nm, and after grinding with a bead mill, 100–300 nm. Adsorption in PBS was significantly higher than in BP for all fractions, and depended on SRL concentration. The fraction obtained after grinding with a ball mill showed maximal SRL adsorption, both in PBS and BP, and slow SRL release, in comparison with other fractions. The 100–300 nm AC fractions were able to adsorb and completely release SRL into BP, in contrast to other fractions, which strongly bound a significant amount of SRL. The data obtained are to be used for controlled SRL delivery, and thus in the modification of drug delivery in biological media.

Nazarkina Z.K. , Savostyanova T.A. , Chelobanov B.P. , Romanova I.V. , Simonov P.A. , Kvon R.I. , Karpenko A.A. , Laktionov P.P.
Activated Carbon for Drug Delivery from Composite Biomaterials: The Effect of Grinding on Sirolimus Binding and Release
Pharmaceutics. 2022. V.14. N7. 1386 :1-15. DOI: 10.3390/pharmaceutics14071386 WOS Scopus РИНЦ AN PMID OpenAlex

Submitted:	May 24, 2022
Accepted:	Jun 28, 2022
Published print:	Jun 30, 2022
Published online:	Jun 30, 2022

Web of science:	WOS:000833836800001
Scopus:	2-s2.0-85133539161
Elibrary:	49158342
Chemical Abstracts:	2022:2066891
PMID:	35890281
OpenAlex:	W4283762255

DB	Citing
Scopus	4
Web of science	4
Elibrary	75
OpenAlex	4