Determination of Elemental Impurities Cd, Pb, As, Hg, Co, V, Ni, Pd, Ru, Ag, Pt, Mo, Al, and Fe in Highly Potent Analgesic Activity Agent by Microwave-Induced Plasma Optical Emission Spectrometry (MIP OES) | Sciact - CRIS-system of Boreskov Institute of Catalysis

Determination of Elemental Impurities Cd, Pb, As, Hg, Co, V, Ni, Pd, Ru, Ag, Pt, Mo, Al, and Fe in Highly Potent Analgesic Activity Agent by Microwave-Induced Plasma Optical Emission Spectrometry (MIP OES) Full article

Journal

Chemical Papers
ISSN: 0366-6352 , E-ISSN: 1336-9075

Output data

Year: 2022, Volume: 76, Pages: 5677–5689 Pages count : 13 DOI: 10.1007/s11696-022-02275-0

Tags

Analgesic activity agent · MIP OES · Sample decomposition

Authors

Zubricheva Daria V. ¹ , Lastovka Anastasiya V. ^1,2 , Il'ina Irina V. ¹ , Volcho Konstantin P. ¹ , Tikhova Vera D. ¹ , Fadeeva Valentina P ¹ , Salakhutdinov Nariman F. ¹

Affiliations

1	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences, 9 Lavrentiev ave, Novosibirsk 630090, Russia
2	Novosibirsk State University, 2 Pirogov St, Novosibirsk 630090, Russia

Two methods for quantifying elemental impurities in a highly potent analgesic activity agent (2R,4aR,7R,8aR)-4,7-dimethyl-2-(thiophen-2-yl)octahydro-2H-chromen-4-ol have been developed using acid decomposition assisted by microwave digestion system or heating in metallic block followed by analyte determination using microwave-induced plasma optical emission spectrometry (MIP OES). Both methods have been validated. The fast linear interference correction (FLIC) and inter-element correction (IEC) methods have been used to take into account possible spectral interferences. Arsenic and mercury have been determined using the multimode sample introduction system (MSIS). The detection limits have been calculated (µg L−1) – 5.4 for Cd, 5.1 for Pb, 11 for As, 1.3 for Hg, 10 for Co, 2.4 for V, 1.4 for Ni. The accuracy of the results was established using an independent inductively coupled plasma mass spectrometry (ICP-MS) method. The relative standard deviation (RSD) (n ≥ 4) was ≤ 12% for Cd, 3.8% for Pb, 6.2% for As, 11% for Hg, 3.0% for V (sample decomposition assisted by heating on metallic block), and 10% for Ni (sample decomposition assisted by microwave radiation). It was shown that the concentration of Cd, As, Hg, Co, V, Ni, Pd, Ru, Ag, Pt, and Mo as impurities in (2R,4aR,7R,8aR)-4,7-dimethyl-2-(thiophen-2-yl)octahydro-2H-chromen-4-ol was lower than the upper limit concentration.

Zubricheva D.V. , Lastovka A.V. , Il'ina I.V. , Volcho K.P. , Tikhova V.D. , Fadeeva V.P. , Salakhutdinov N.F.
Determination of Elemental Impurities Cd, Pb, As, Hg, Co, V, Ni, Pd, Ru, Ag, Pt, Mo, Al, and Fe in Highly Potent Analgesic Activity Agent by Microwave-Induced Plasma Optical Emission Spectrometry (MIP OES)
Chemical Papers. 2022. V.76. P.5677–5689. DOI: 10.1007/s11696-022-02275-0 WOS Scopus AN OpenAlex

Submitted:	Sep 25, 2021
Accepted:	May 8, 2022
Published online:	Jun 1, 2022
Published print:	Sep 1, 2022

Web of science:	WOS:000804538700002
Scopus:	2-s2.0-85136785744
Chemical Abstracts:	2022:1452996
OpenAlex:	W4281748272

DB	Citing
Scopus	2
Web of science	3
OpenAlex	2