Propane-d(6) Heterogeneously Hyperpolarized by Parahydrogen | Sciact - CRIS-system of Boreskov Institute of Catalysis

Propane-d(6) Heterogeneously Hyperpolarized by Parahydrogen Full article

Journal

The Journal of Physical Chemistry C
ISSN: 1932-7447 , E-ISSN: 1932-7455

Output data

Year: 2014, Volume: 118, Number: 48, Pages: 28234-28243 Pages count : 10 DOI: 10.1021/jp508719n

Tags

Gases; Magnetic fields; Spin dynamics; Spin polarization; Synthesis (chemical)

Authors

Kovtunov Kirill V. ^1,2 , Truong Milton L. ³ , Barskiy Danila A. ^1,2 , Salnikov Oleg G. ^1,2 , Bukhtiyarov Valery I. ⁷ , Coffey Aaron M. ^3,4 , Waddell Kevin W. ^3,5 , Koptyug Igor V. ^1,2 , Chekmenev Eduard Y. ^3,4,5,6

Affiliations

1	International Tomography Center, 3A Institutskaya St., Novosibirsk 630090, Russia
2	Novosibirsk State University, 2 Pirogova St., Novosibirsk, 630090, Russia
3	Institute of Imaging Science, Department of Radiology, Vanderbilt University, Nashville, Tennessee 37232-2310, United States
4	Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37232-2310, United States
5	Vanderbilt University
6	Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37232-2310, United States
7	Boreskov Institute of Catalysis, SB RAS, 5 Acad. Lavrentiev Pr., Novosibirsk 630090, Russia

Funding (9)

1	Russian Foundation for Basic Research	14-03-93183
2	Russian Science Foundation	14-13-00445
3	Russian Science Foundation	14-35-00020
4	National Science Foundation	CHE-1416268
5	National Institutes of Health	1R21EB018014
6	National Institutes of Health	3R00CA134749-02S1
7	National Institutes of Health	5P50 CA128323-03
8	National Institutes of Health	5R00 CA134749-03
9	United States Department of Defense	W81XWH-12-1-0159/BC112431

Long-lived spin states of hyperpolarized propane-d6 gas were demonstrated following pairwise addition of parahydrogen gas to propene-d6 using heterogeneous parahydrogen-induced polarization (HET-PHIP). Hyperpolarized molecules were synthesized using Rh/TiO2 solid catalyst with 1.6 nm Rh nanoparticles. Hyperpolarized (PH ∼ 1%) propane-d6 was detected at high magnetic field (9.4 T) spectroscopically and by high-resolution 3D gradient-echo MRI (4.7 T) as the gas flowed through the radiofrequency coil with a spatial and temporal resolution of 0.5 × 0.5 × 0.5 mm3 and 17.7 s, respectively. Stopped-flow hyperpolarized propane-d6 gas was also detected at 0.0475 T with an observed nuclear spin polarization of PH ∼ 0.1% and a relatively long lifetime with T1,eff = 6.0 ± 0.3 s. Importantly, it was shown that the hyperpolarized protons of the deuterated product obtained via pairwise parahydrogen addition could be detected directly at low magnetic field. Importantly, the relatively long low-field T1,eff of HP propane-d6 gas is not susceptible to paramagnetic impurities as tested by exposure to ∼0.2 atm oxygen. This long lifetime and nontoxic nature of propane gas could be useful for bioimaging applications including potentially pulmonary low-field MRI. The feasibility of high-resolution low-field 2D gradient-echo MRI was demonstrated with 0.88 × 0.88 mm2 spatial and ∼0.7 s temporal resolution, respectively, at 0.0475 T.

Kovtunov K.V. , Truong M.L. , Barskiy D.A. , Salnikov O.G. , Bukhtiyarov V.I. , Coffey A.M. , Waddell K.W. , Koptyug I.V. , Chekmenev E.Y.
Propane-d(6) Heterogeneously Hyperpolarized by Parahydrogen

The Journal of Physical Chemistry C. 2014. V.118. N48. P.28234-28243. DOI: 10.1021/jp508719n WOS Scopus РИНЦ ANCAN PMID OpenAlex

Full text from publisher

Submitted:	Aug 28, 2014
Accepted:	Nov 6, 2014
Published online:	Nov 19, 2014
Published print:	Dec 4, 2014

Web of science:	WOS:000345891900072
Scopus:	2-s2.0-84915747203
Elibrary:	24012436
Chemical Abstracts:	2014:1883026
Chemical Abstracts (print):	161:753649
PMID:	25506406
OpenAlex:	W2017929231

DB	Citing
Web of science	67
Scopus	67
Elibrary	68
OpenAlex	73