Abstract: This study was conducted to evaluate the effects of long-term administration of a new herbal composition of leuzea and cranberry meal extracts at a dose of 70:500 mg/kg in healthy and pathological mice. After 4 weeks of daily composition administration to healthy CD-1 mice and C57BL/6 mice with diet-induced metabolic syndrome, oral glucose tolerance test (OGTT), serum biochemical examination and histology of internal organs were performed. Additionally, histological examination of white and brown adipose tissue was performed to evaluate the ability of the composition to prevent abdominal obesity in C57BL/6Ay (agouti yellow) mice. The results showed that the composition increased tissue sensitivity to glucose in healthy CD-1 mice; at the same time, it did not worsen the course of pathological processes in pathological mice. In both cases, the application of the developed composition was safe and contributed to the restoration of metabolic parameters.

Cite: Khalikova D. , An’kov S. , Zhukova N. , Tolstikova T. , Popov S. , Saiko A.
Effect of the Composition of Leuzea and Cranberry Meal Extracts on Metabolic Processes in Norm and Pathology
Pharmaceuticals. 2023. V.16. N5. 768 :1-13. DOI: 10.3390/ph16050768 WOS Scopus ANCAN PMID OpenAlex

Dates:

Submitted:	Apr 17, 2023
Accepted:	May 17, 2023
Published print:	May 19, 2023
Published online:	May 19, 2023

Identifiers:

Web of science:	WOS:000996654500001
Scopus:	2-s2.0-85160553223
Chemical Abstracts:	2023:1150396
Chemical Abstracts (print):	183:111230
PMID:	37242551
OpenAlex:	W4377092448

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DB	Citing
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