Xenon-Induced Effects in Relieving Experimental Acute Respiratory Distress Syndrome | Sciact - CRIS-system of Boreskov Institute of Catalysis

Xenon-Induced Effects in Relieving Experimental Acute Respiratory Distress Syndrome Full article

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888 , E-ISSN: 1573-8221

Output data

Year: 2023, Volume: 174, Number: 5, Pages: 605-609 Pages count : 5 DOI: 10.1007/s10517-023-05755-9

Tags

xenon; acute respiratory distress syndrome; acidin-pepsin; E. coli; hemostasis

Authors

Fedorova E.P. ¹ , Filonova M.V. ^1,3 , Churin A.A. ^1,3 , Naumov S.A. ¹ , Nikiforov P.E. ¹ , Sandrikina L.A. ¹ , Evtushenko D.N. ³ , Udut E.V. ^1,2 , Popov O.S. ² , Naumov S.S. ² , Fomina T.I. ¹ , Udut V.V. ^1,3

Affiliations

1	E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia
2	Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia
3	Tomsk National Research State University, Tomsk, Russia

The effects of inhalations of an oxygen-xenon (70%/30%) mixture were studied in two models of acute respiratory distress syndrome caused by intratracheal administration of 0.5 mg/kg LPS or 0.04 ml acidin-pepsin (pH 1.2). Inhalation of the oxygen-xenon mixture inhibited the development and reduced the intensity of the inflammatory process in the lung tissue, which was assessed by the dynamics of lung weight and body weight of animals: the therapeutic exposure decreased both parameters. It was found that the thrombogenic stimulus, pathognomonic for the development of acute respiratory distress syndrome, decreased under the effect of oxygen-xenon inhalations, while the level of natural anticoagulant antithrombin III increased.

Fedorova E.P. , Filonova M.V. , Churin A.A. , Naumov S.A. , Nikiforov P.E. , Sandrikina L.A. , Evtushenko D.N. , Udut E.V. , Popov O.S. , Naumov S.S. , Fomina T.I. , Udut V.V.
Xenon-Induced Effects in Relieving Experimental Acute Respiratory Distress Syndrome
Bulletin of Experimental Biology and Medicine. 2023. V.174. N5. P.605-609. DOI: 10.1007/s10517-023-05755-9 WOS Scopus ANCAN PMID OpenAlex

Федорова Е.П. , Филонова М.В. , Чурин А.А. , Наумов С.А. , Никифоров П.Е. , Сандрикина Л.А. , Евтушенко Д.Н. , Удут Е.В. , Попов О.С. , Наумов С.С. , Фомина Т.И. , Удут В.В.
Ксенониндуцированные эффекты в купировании экспериментального острого респираторного дистресс-синдрома
Бюллетень экспериментальной биологии и медицины. 2022. Т.174. №11. С.560-564. DOI: 10.47056/0365-9615-2022-174-11-560-564 OpenAlex

Submitted:	Jul 6, 2022
Published print:	Mar 1, 2023

Web of science:	WOS:000967784400005
Scopus:	2-s2.0-85152452445
Chemical Abstracts:	2023:783115
Chemical Abstracts (print):	182:408822
PMID:	37040041
OpenAlex:	W4364353344

DB	Citing
OpenAlex	1
Web of science	1
Scopus	1