Detoxification Treatment in Gynecology Using a Modified Molded Sorbent | Sciact - CRIS-system of Boreskov Institute of Catalysis

Detoxification Treatment in Gynecology Using a Modified Molded Sorbent Full article

Journal

Best Practice & Research Clinical Obstetrics & Gynaecology
ISSN: 1521-6934 , E-ISSN: 1532-1932

Output data

Year: 2023, Volume: 88, Article number : 102346, Pages count : 11 DOI: 10.1016/j.bpobgyn.2023.102346

Tags

Labor; Postpartum endometritis; IR spectroscopy; Cesarean section; Cytokines; Pathogenic microflora; Antibiotics; Antibiotic resistance; Toxins

Authors

Barinov S.V. ¹ , Di Renzo G.C. ^2,3,7,8 , Tsibizova V.I. ^6,7 , Shifman E.М. ⁴ , Leont'eva N.N. ⁵ , Arbuzov A.B. ⁵

Affiliations

1	Federal State Budget Institution of Higher Education, “Omsk State Medical University” of the Russian Ministry of Health, Omsk, Russian Federation
2	Centre for Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy
3	Wayne State University Medical School and Perinatal Research Branch, NIH-NICHD, Detroit, MI, 48201, USA
4	Department of Anesthesiology and Сritical Care of Moscow Regional M.V. Vladimirsky Moscow`s Regional Research Clinical Institute, Moscow, Russian Federation
5	Center of New Chemical Technologies Boreskov Institute of Catalysis, Omsk, Russian Federation
6	Institute of Perinatology and Pediatrics, Almazov National Medical Research Centre, Saint-Petersburg, Russian Federation
7	PREIS International and European School of Perinatal, Neonatal and Reproductive Medicine, Florence, Italy
8	Department of Obstetrics, Gynecology and Perinatal Medicine of the Clinical Institute of Children's Health Named After N.F. Filatov, I.M. Sechenov First State Medical University Under Ministry of Health of the Russian Federation, Moscow, Russian Federation

Postpartum endometritis is a common complication of cesarean section, the progression of which often leads to the loss of the uterus and the patient's fertility. We evaluated a detoxification therapy for treating patients with postpartum endometritis using an intrauterine application of a modified molded sorbent containing polyvinylpyrrolidone. A retrospective, controlled study included 124 patients with postpartum endometritis. The study group, n = 63, was composed of puerperae with postpartum endometritis after cesarean section, receiving antibacterial therapy in combination with the intrauterine application of a molded modified sorbent containing polyvinylpyrrolidone (FSMP) for 24 h daily for 5 days. The control group, n = 61, was composed of puerperae with postpartum endometritis after cesarean section, receiving antibacterial treatment only. The uterine cavity was infected by coccal flora (Enterococcus faecalis (26.6%), Staphylococcus spp. (21.3%), E. faecium (14.3%), and Gram-negative Escherichia coli (9.6%). A combination of these microorganisms was present in 40.5% of crops. Antibiotic resistance was detected in 53.6%–68.3% of the cases. In the study group, we observed: a faster and higher decrease in neutrophils (p < 0.05); a lower uterine concentration of pro-inflammatory cytokines: interleukin-1 beta (IL-1β) and tumor necrosis factor α (TNFα) - 4.0 and 3.2 times, respectively, compared with the control group (p < 0.05); and a significant decrease in the uterus volume and cavity (M-echo). Using a newly modified sorbent associated with antibiotic treatment in patients with postpartum endometritis, compared with antibiotics alone, we showed a sharp reduction of inflammatory parameters, residual microorganism growth, and faster uterine volume involution. Moreover, the frequency of hysterectomy decreased by 14.4 times.

Barinov S.V. , Di Renzo G.C. , Tsibizova V.I. , Shifman E.М. , Leont'eva N.N. , Arbuzov A.B.
Detoxification Treatment in Gynecology Using a Modified Molded Sorbent
Best Practice & Research Clinical Obstetrics & Gynaecology. 2023. V.88. 102346 :1-11. DOI: 10.1016/j.bpobgyn.2023.102346 WOS Scopus РИНЦ PMID OpenAlex

Published online:	May 6, 2023
Published print:	Jun 1, 2023

Web of science:	WOS:001012904800001
Scopus:	2-s2.0-85159923866
Elibrary:	61736846
PMID:	37225639
OpenAlex:	W4372402118

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