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Toward Lung Ventilation Imaging Using Hyperpolarized Diethyl Ether Gas Contrast Agent Научная публикация

Журнал Chemistry - A European Journal
ISSN: 0947-6539 , E-ISSN: 1521-3765
Вых. Данные Год: 2024, Том: 30, Номер: 25, Номер статьи : e202304071, Страниц : 5 DOI: 10.1002/chem.202304071
Ключевые слова Diethyl ether , parahydrogen , hyperpolarization, MRI eneous catalysis
Авторы Ariyasingha Nuwandi M. 1 , Chowdhury Md Raduanul H. 1 , Samoilenko Anna 1 , Salnikov Oleg G. 2 , Chukanov Nikita V. 2 , Kovtunova Larisa M. 2,3 , Bukhtiyarov Valerii I. 3 , Shi Zhongjie 1 , Luo Kehuan 1 , Tan Sidhartha 1 , Koptyug Igor V. 2 , Goodson Boyd M. 4 , Chekmenev Eduard Y. 1
Организации
1 Department of Chemistry, Karmanos Cancer Institute (KCI), Department of Pediatrics, Wayne State University, Detroit, MI 48202 (USA)
2 International Tomography Center SB RAS, 3A Institutskaya Street, Novosibirsk, 630090 (Russia)
3 Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr, Novosibirsk, 630090 (Russia)
4 School of Chemical and Biomolecular Sciences, Southern Illinois University, Carbondale, IL, 62901 (USA)

Информация о финансировании (6)

1 National Institutes of Health 1R21HL154032-01
2 National Heart Lung and Blood Institute 1F32HL160108
3 Российский научный фонд 21-73-10105 (121121600301-4)
4 National Institutes of Health R01NS114972
5 National Institutes of Health R01NS117146
6 National Institutes of Health R01NS130258

Реферат: Hyperpolarized 129Xe gas was FDA-approved as an inhalable contrast agent for magnetic resonance imaging of a wide range of pulmonary diseases in December 2022. Despite the remarkable success in clinical research settings, the widespread clinical translation of HP 129Xe gas faces two critical challenges: the high cost of the relatively low-throughput hyperpolarization equipment and the lack of 129Xe imaging capability on clinical MRI scanners, which have narrow-bandwidth electronics designed only for proton (1H) imaging. To solve this translational grand challenge of gaseous hyperpolarized MRI contrast agents, here we demonstrate the utility of batch-mode production of proton-hyperpolarized diethyl ether gas via heterogenous pairwise addition of parahydrogen to ethyl vinyl ether. An approximately 0.1-liter bolus of hyperpolarized diethyl ether gas was produced in 1 second and injected in excised rabbit lungs. Lung ventilation imaging was performed using sub-second 2D MRI with up to 2x2 mm2 in-plane resolution using a clinical 0.35 T MRI scanner without any modifications. This feasibility demonstration paves the way for the use of inhalable diethyl ether as a gaseous contrast agent for pulmonary MRI applications using any clinical MRI scanner.
Библиографическая ссылка: Ariyasingha N.M. , Chowdhury M.R.H. , Samoilenko A. , Salnikov O.G. , Chukanov N.V. , Kovtunova L.M. , Bukhtiyarov V.I. , Shi Z. , Luo K. , Tan S. , Koptyug I.V. , Goodson B.M. , Chekmenev E.Y.
Toward Lung Ventilation Imaging Using Hyperpolarized Diethyl Ether Gas Contrast Agent
Chemistry - A European Journal. 2024. V.30. N25. e202304071 :1-5. DOI: 10.1002/chem.202304071 WOS Scopus РИНЦ CAPlus PMID OpenAlex
Даты:
Поступила в редакцию: 13 февр. 2024 г.
Опубликована online: 21 февр. 2024 г.
Принята к публикации: 21 мар. 2024 г.
Опубликована в печати: 2 мая 2024 г.
Идентификаторы БД:
Web of science: WOS:001182457900001
Scopus: 2-s2.0-85187185419
РИНЦ: 66339245
Chemical Abstracts: 2024:573011
PMID (PubMed): 38381807
OpenAlex: W4391992536
Цитирование в БД:
БД Цитирований
OpenAlex 16
Scopus 16
Web of science 16
Альметрики: