Toward Lung Ventilation Imaging Using Hyperpolarized Diethyl Ether Gas Contrast Agent | Sciact - CRIS-система Института катализа

Toward Lung Ventilation Imaging Using Hyperpolarized Diethyl Ether Gas Contrast Agent Научная публикация

Журнал

Chemistry - A European Journal
ISSN: 0947-6539 , E-ISSN: 1521-3765

Вых. Данные

Год: 2024, Том: 30, Номер: 25, Номер статьи : e202304071, Страниц : 5 DOI: 10.1002/chem.202304071

Ключевые слова

Diethyl ether , parahydrogen , hyperpolarization, MRI eneous catalysis

Авторы

Ariyasingha Nuwandi M. ¹ , Chowdhury Md Raduanul H. ¹ , Samoilenko Anna ¹ , Salnikov Oleg G. ² , Chukanov Nikita V. ² , Kovtunova Larisa M. ^2,3 , Bukhtiyarov Valerii I. ³ , Shi Zhongjie ¹ , Luo Kehuan ¹ , Tan Sidhartha ¹ , Koptyug Igor V. ² , Goodson Boyd M. ⁴ , Chekmenev Eduard Y. ¹

Организации

1	Department of Chemistry, Karmanos Cancer Institute (KCI), Department of Pediatrics, Wayne State University, Detroit, MI 48202 (USA)
2	International Tomography Center SB RAS, 3A Institutskaya Street, Novosibirsk, 630090 (Russia)
3	Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr, Novosibirsk, 630090 (Russia)
4	School of Chemical and Biomolecular Sciences, Southern Illinois University, Carbondale, IL, 62901 (USA)

Информация о финансировании (6)

1	National Institutes of Health	1R21HL154032-01
2	National Heart Lung and Blood Institute	1F32HL160108
3	Российский научный фонд	21-73-10105 (121121600301-4)
4	National Institutes of Health	R01NS114972
5	National Institutes of Health	R01NS117146
6	National Institutes of Health	R01NS130258

Hyperpolarized 129Xe gas was FDA-approved as an inhalable contrast agent for magnetic resonance imaging of a wide range of pulmonary diseases in December 2022. Despite the remarkable success in clinical research settings, the widespread clinical translation of HP 129Xe gas faces two critical challenges: the high cost of the relatively low-throughput hyperpolarization equipment and the lack of 129Xe imaging capability on clinical MRI scanners, which have narrow-bandwidth electronics designed only for proton (1H) imaging. To solve this translational grand challenge of gaseous hyperpolarized MRI contrast agents, here we demonstrate the utility of batch-mode production of proton-hyperpolarized diethyl ether gas via heterogenous pairwise addition of parahydrogen to ethyl vinyl ether. An approximately 0.1-liter bolus of hyperpolarized diethyl ether gas was produced in 1 second and injected in excised rabbit lungs. Lung ventilation imaging was performed using sub-second 2D MRI with up to 2x2 mm2 in-plane resolution using a clinical 0.35 T MRI scanner without any modifications. This feasibility demonstration paves the way for the use of inhalable diethyl ether as a gaseous contrast agent for pulmonary MRI applications using any clinical MRI scanner.

Ariyasingha N.M. , Chowdhury M.R.H. , Samoilenko A. , Salnikov O.G. , Chukanov N.V. , Kovtunova L.M. , Bukhtiyarov V.I. , Shi Z. , Luo K. , Tan S. , Koptyug I.V. , Goodson B.M. , Chekmenev E.Y.
Toward Lung Ventilation Imaging Using Hyperpolarized Diethyl Ether Gas Contrast Agent
Chemistry - A European Journal. 2024. V.30. N25. e202304071 :1-5. DOI: 10.1002/chem.202304071 WOS Scopus РИНЦ CAPlus PMID OpenAlex

Поступила в редакцию:	13 февр. 2024 г.
Опубликована online:	21 февр. 2024 г.
Принята к публикации:	21 мар. 2024 г.
Опубликована в печати:	2 мая 2024 г.

Web of science:	WOS:001182457900001
Scopus:	2-s2.0-85187185419
РИНЦ:	66339245
Chemical Abstracts:	2024:573011
PMID (PubMed):	38381807
OpenAlex:	W4391992536

БД	Цитирований
OpenAlex	19
Scopus	20
Web of science	18