Transient Protein–Protein Complexes in Base Excision Repair | Sciact - CRIS-system of Boreskov Institute of Catalysis

Transient Protein–Protein Complexes in Base Excision Repair Review

Journal

Journal of Biomolecular Structure and Dynamics
ISSN: 1538-0254

Output data

Year: 2018, Volume: 37, Number: 17, Pages: 4407-4418 Pages count : 12 DOI: 10.1080/07391102.2018.1553741

Tags

Base excision repair; DNA glycosylases; AP endonucleases; transient protein-protein complexes

Authors

Endutkin Anton V. ^1,2,3 , Yudkina Anna V. ^1,2 , Sidorenko Viktoriya S. ⁴ , Zharkov Dmitry O. ^1,2

Affiliations

1	SB RAS Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia
2	Novosibirsk State University, Novosibirsk, Russia
3	Podalirius Ltd., Novosibirsk, Russia
4	Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA

Transient protein–protein complexes are of great importance for organizing multiple enzymatic reactions into productive reaction pathways. Base excision repair (BER), a process of critical importance for maintaining genome stability against a plethora of DNA-damaging factors, involves several enzymes, including DNA glycosylases, AP endonucleases, DNA polymerases, DNA ligases and accessory proteins acting sequentially on the same damaged site in DNA. Rather than being assembled into one stable multisubunit complex, these enzymes pass the repair intermediates between them in a highly coordinated manner. In this review, we discuss the nature and the role of transient complexes arising during BER as deduced from structural and kinetic data. Almost all of the transient complexes are DNA-mediated, although some may also exist in solution and strengthen under specific conditions. The best-studied example, the interactions between DNA glycosylases and AP endonucleases, is discussed in more detail to provide a framework for distinguishing between stable and transient complexes based on the kinetic data.

Endutkin A.V. , Yudkina A.V. , Sidorenko V.S. , Zharkov D.O.
Transient Protein–Protein Complexes in Base Excision Repair
Journal of Biomolecular Structure and Dynamics. 2018. V.37. N17. P.4407-4418. DOI: 10.1080/07391102.2018.1553741 WOS Scopus OpenAlex

Web of science:	WOS:000489235600001
Scopus:	2-s2.0-85059349538
OpenAlex:	W2902349805

DB	Citing
Web of science	16
OpenAlex	18
Scopus	16