Abstract: Platinum complexes are among the most commonly prescribed drugs in cancer therapy but show significant toxicity to healthy tissues as a side effect. Platinum polyoxometalates are platinum complexes liganded with cluster anions consisting of oxygen atoms and transition metals. Their properties related to a potential use as anticancer drugs have never been studied. In this paper, we have investigated the effect of platinum (IV) polyoxoniobate of the [Nb6O19{Pt(OH)2}]2 structure containing two platinum centers and two polynuclear Lindqvist type anions on the activity of a number of DNA polymerases belonging to different families (Klenow fragment of Escherichia coli DNA polymerase I, bacteriophage RB69 DNA polymerase, human DNA polymerases β and κ, DNA polymerase IV from Sulfolobus solfataricus). On its own, platinum polyoxoniobate did not act as an inhibitor of DNA polymerases, but was capable of forming adducts with DNA.

Cite: Yudkina A.V. , Sokolov M.N. , Abramov P.A. , Grin I.R. , Zharkov D.O.
Platinum Polyoxoniobates Form Adducts with DNA
Russian Journal of Bioorganic Chemistry. 2019. V.45. N6. P.641-646. DOI: 10.1134/s1068162019060414 WOS Scopus OpenAlex

Dates:

Submitted:	Jun 24, 2019
Accepted:	Jul 25, 2019
Published print:	Nov 1, 2019
Published online:	Jan 16, 2020

Identifiers:

Web of science:	WOS:000520225900023
Scopus:	2-s2.0-85077850998
OpenAlex:	W2999433920

Citing:

DB	Citing
Web of science	5
OpenAlex	6
Scopus	5

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