Template-Directed Crystallization of Carbamazepine Form II from Palmitic Acid Melt – a Key to Understand Mechanically-Induced Polymorphism of Carbamazepine | Sciact - CRIS-system of Boreskov Institute of Catalysis

Template-Directed Crystallization of Carbamazepine Form II from Palmitic Acid Melt – a Key to Understand Mechanically-Induced Polymorphism of Carbamazepine Full article

Journal

CrystEngComm
ISSN: 1466-8033

Output data

Year: 2024, DOI: 10.1039/d4ce00906a

Authors

Losev Evgeniy A. ^1,2,3,4 , Zheltikova Daria Ya. ^1,2 , Drebushchak Valeri A. ^1,2 , Boldyreva Elena V. ^1,2,3

Affiliations

1	Sobolev Institute of Geology and Mineralogy SB RAS, Koptyuga Ave., 3, 630090, Russia
2	Novosibirsk State University, ul. Pirogova, 2, Novosibirsk, 630090, Russia
3	Boreskov Institute of Catalysis SB RAS, Lavrentieva Ave., 5, 630090, Russia
4	Voevodsky Institute of Chemical Kinetics and Combustion SB RAS, Novosibirsk, 630090 Russia

Funding (1)

Russian Science Foundation

24-13-00140

Heating a single crystal of carbamazepine (III) (the thermodynamically stable form) in contact with solid palmitic acid resulted in melting of palmitic acid and the growth of the crystals of carbamazepine (II) (the least stable polymorph) at the interface “carbamazepine (III) crystal – palmitic acid melt”. The study suggests a possible mechanism of the transformation of carbamazepine (III) into carbamazepine (II) on mechanical treatment with palmitic acid as an additive.

Losev E.A. , Zheltikova D.Y. , Drebushchak V.A. , Boldyreva E.V.
Template-Directed Crystallization of Carbamazepine Form II from Palmitic Acid Melt – a Key to Understand Mechanically-Induced Polymorphism of Carbamazepine
CrystEngComm. 2024. DOI: 10.1039/d4ce00906a OpenAlex

Submitted:	Sep 9, 2024
Accepted:	Nov 14, 2024
Published online:	Nov 15, 2024

OpenAlex:

W4404417203

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