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Template-Directed Crystallization of Carbamazepine Form II from Palmitic Acid Melt – a Key to Understand Mechanically-Induced Polymorphism of Carbamazepine Full article

Journal CrystEngComm
ISSN: 1466-8033
Output data Year: 2024, Volume: 26, Number: 48, Pages: 6796-6804 Pages count : 9 DOI: 10.1039/d4ce00906a
Tags X-RAY-DIFFRACTION; SOLVENT INCLUSION; CRYSTAL; TRANSFORMATION; DRUG; NUCLEATION
Authors Losev Evgeniy A. 1,2,3,4 , Zheltikova Daria Ya. 1,2 , Drebushchak Valeri A. 1,2 , Boldyreva Elena V. 1,2,3
Affiliations
1 Sobolev Institute of Geology and Mineralogy SB RAS, Koptyuga Ave., 3, 630090, Russia
2 Novosibirsk State University, ul. Pirogova, 2, Novosibirsk, 630090, Russia
3 Boreskov Institute of Catalysis SB RAS, Lavrentieva Ave., 5, 630090, Russia
4 Voevodsky Institute of Chemical Kinetics and Combustion SB RAS, Novosibirsk, 630090 Russia

Funding (1)

1 Russian Science Foundation 24-13-00140

Abstract: Heating a single crystal of carbamazepine (III) (the thermodynamically stable form) in contact with solid palmitic acid resulted in melting of palmitic acid and the growth of the crystals of carbamazepine (II) (the least stable polymorph) at the interface “carbamazepine (III) crystal – palmitic acid melt”. The study suggests a possible mechanism of the transformation of carbamazepine (III) into carbamazepine (II) on mechanical treatment with palmitic acid as an additive.
Cite: Losev E.A. , Zheltikova D.Y. , Drebushchak V.A. , Boldyreva E.V.
Template-Directed Crystallization of Carbamazepine Form II from Palmitic Acid Melt – a Key to Understand Mechanically-Induced Polymorphism of Carbamazepine
CrystEngComm. 2024. V.26. N48. P.6796-6804. DOI: 10.1039/d4ce00906a WOS Scopus РИНЦ OpenAlex
Dates:
Published print: Jan 28, 2024
Submitted: Sep 9, 2024
Accepted: Nov 14, 2024
Published online: Nov 15, 2024
Identifiers:
Web of science: WOS:001363268200001
Scopus: 2-s2.0-85210303002
Elibrary: 79399356
OpenAlex: W4404417203
Citing: Пока нет цитирований
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