Gel-Phase Synthesis and pH-Sensitive Swelling-Structure Relationships of N-Carboxyethylchitosan | Sciact - CRIS-system of Boreskov Institute of Catalysis

Gel-Phase Synthesis and pH-Sensitive Swelling-Structure Relationships of N-Carboxyethylchitosan Full article

Journal

Eurasian Journal of Chemistry
ISSN: 2959-0663

Output data

Year: 2025, DOI: 10.31489/2959-0663/2-25-6

Tags

Carboxyethylchitosan, biopolymer, gel phase synthesis, derivatization, Michael reaction, pH-sensitive swelling, porosity, green chemistry

Authors

Dubovskaia Polina I. ¹ , Saeidi Arsalan ^1,2 , Pronchenko Anna A. ¹ , Drannikova Anastasiia I. ¹ , Lukoyanov Ivan A. ^1,3 , Aripova Farida K. ^1,4 , Savenko Mariia E. ¹ , Veretennikova Elizaveta A. ⁵ , Pestov Alexander V. ⁵ , Litvinova Ekaterina A. ¹ , Drannikov Aleksandr A. ¹

Affiliations

1	Novosibirsk State Technical University, Novosibirsk, Russia
2	Novosibirsk State University, Novosibirsk, Russia
3	Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
4	Novosibirsk State Agrarian University, Novosibirsk, Russia
5	I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia

Funding (1)

Ministry of Science and Higher Education of the Russian Federation

Приоритет 2030

The applicability of native chitosan-based compositions is constrained by their limited solubility in weakly alkaline and neutral media, a consequence of inherent structural features. To overcome this limitation, carboxyalkylation strategies such as the gel-phase Michael synthesis of N-carboxyethylchitosan (N-CEC) were investigated with a focus on optimizing reaction parameters to enhance yield and tailor biopolymer properties. Structural confirmation of the synthesized polymers was performed via FT-IR and SEM, while elemental analysis quantified the degree of substitution (DS), which correlated with temperature in the following way: DS = 0.96–1.10 at 50 °C, 1.07–1.12 at 60 °C and 1.16–1.32 at 70 °C. Porosity measurements indicated pore sizes ranging from 50 to 200 µm in all samples; however, total porosity varied significantly, reaching a maximum of 15 % at 70 °C and decreasing to 4–10 % at lower temperatures. N-CEC exhibited pH‑dependent swelling, with minimal expansion (100–150 %) at low pH and a 2–3-fold increase at pH > 7, which was attributed to COO⁻ group formation. These findings position N-CEC as a promising material for pH-responsive applications.

Dubovskaia P.I. , Saeidi A. , Pronchenko A.A. , Drannikova A.I. , Lukoyanov I.A. , Aripova F.K. , Savenko M.E. , Veretennikova E.A. , Pestov A.V. , Litvinova E.A. , Drannikov A.A.
Gel-Phase Synthesis and pH-Sensitive Swelling-Structure Relationships of N-Carboxyethylchitosan
Eurasian Journal of Chemistry. 2025. DOI: 10.31489/2959-0663/2-25-6 WOS OpenAlex

Submitted:	Mar 14, 2025
Accepted:	May 20, 2025
Published online:	Jun 4, 2025

Web of science:	WOS:001504149700001
OpenAlex:	W4411034586

Пока нет цитирований