Treatment of Ebola Virus Disease: From Serotherapy to the Use of Monoclonal Antibodies | Sciact - CRIS-system of Boreskov Institute of Catalysis

Treatment of Ebola Virus Disease: From Serotherapy to the Use of Monoclonal Antibodies Full article

Journal

Antibodies
ISSN: 2073-4468

Output data

Year: 2025, Volume: 14, Number: 1, Article number : 22, Pages count : 24 DOI: 10.3390/antib14010022

Tags

Ebola virus disease; filoviruses; passive immunization; neutralizing antibodies; monoclonal antibodies

Authors

Shcherbakov Dmitriy N. ¹ , Isaeva Anastasiya A. ¹ , Mustaev Egor A. ^2,3

Affiliations

1	State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, Koltsovo 630559, Russia
2	Department of Natural Sciences, Novosibirsk State University, Pirogova st., 2, Novosibirsk 630090, Russia
3	Synchrotron Radiation Facility—Siberian Circular Photon Source “SKlF” Boreskov Institute of Catalysis of Siberian Branch of the Russian Academy of Sciences, Nikolskiy pr-t, 1, Koltsovo 630559, Russia

Ebola virus disease (EVD) is an acute illness with a high-case fatality rate (CFR) caused by an RNA virus belonging to the Filoviridae family. Over the past 50 years, regular EVD outbreaks have been reported. The West African EVD outbreak of 2013–2016 proved to be significantly more widespread and complex than previous ones, resulting in approximately 11,000 deaths. A coordinated international effort was required to bring the outbreak under control. One of the main challenges faced by clinicians and researchers combating EVD was the absence of vaccines and preventive treatments. Only recently have efforts led to the development of effective therapeutic options. Among these, monoclonal antibody-based drugs have emerged as the most promising agents for the urgent treatment of EVD. This article aims to review the key milestones in the development of antibody-based therapies for EVD, tracing the journey from the use of convalescent serum to the creation of effective monoclonal antibody-based drugs and their combinations

Shcherbakov D.N. , Isaeva A.A. , Mustaev E.A.
Treatment of Ebola Virus Disease: From Serotherapy to the Use of Monoclonal Antibodies
Antibodies. 2025. V.14. N1. 22 :1-24. DOI: 10.3390/antib14010022 Scopus OpenAlex publication_identifier_short.sciact_skif_identifier_type

Submitted:	Dec 8, 2024
Accepted:	Feb 19, 2025
Published online:	Mar 5, 2025

Scopus:	2-s2.0-105001155395
OpenAlex:	W4408218950
publication_identifier.sciact_skif_identifier_type:	3963

DB	Citing
Scopus	1
OpenAlex	2