A Wireless Magnetoelectric-Driven Strategy to Boost Nose-to-Brain Drug Delivery with Core-Shell Nanotransducers
Full article
| Journal |
Journal of Controlled Release
ISSN: 0168-3659
|
| Output data |
Year: 2026,
Volume: 389,
Article number
: 114421,
Pages count
: 22
DOI:
10.1016/j.jconrel.2025.114421
|
| Tags |
Magnetoelectric nanotransducers; Biocompatible nanomaterials; Magnetic resonance imaging; Wireless electrostimulation; Intranasal administration; Nose-to-brain drug delivery; Neuronal modulation |
| Authors |
Chernozem Roman V.
1
,
Romashchenko Alexander V.
1,2,3,4
,
Chernozem Polina V.
1
,
Urakova Alina O.
1
,
Koptsev Danila A.
1
,
Surmeneva Maria A.
1
,
Grubova Irina
1
,
Wagner Dmitry V.
5
,
Gerasimov Evgeny Yu.
6
,
Solovieva Olga I.
2
,
Razumov Ivan A.
2
,
Morozova Ksenia N.
2
,
Kiseleva Elena V.
2
,
Sharapova Marina B.
2
,
Zuev Daniil S.
2
,
Silvanovich Elizaveta K.
2
,
Ibraeva Azhar Zh.
1,2
,
Vechkapova Svetlana O.
3
,
Nosov Georgy A.
4,7
,
Medvedeva Snezhanna
13
,
Kozhevnikova Elena
13
,
Kon'kova Tatyana V.
8
,
Sukhov Boris G.
8
,
Kazantsev Sergey O.
9
,
Lozhkomoev Aleksandr S.
9
,
Romanyuk Konstantin N.
10
,
Wu Chengheng
11
,
Fan Hongsong
11
,
Ding Bin
12
,
Kholkin Andrei L.
10
,
Surmenev Roman A.
1
|
| Affiliations |
| 1 |
National Research Tomsk Polytechnic University, Tomsk 634050, Russia
|
| 2 |
Federal research center Institute of Cytology and Genetics (ICG), Siberian Branch of Russian Academy of Sciences (SB RAS), Novosibirsk, 630090, Russia
|
| 3 |
Federal Research Center for Information and Computational Technologies, Novosibirsk 630090, Russia
|
| 4 |
LLC LIFT, Moscow 121205, Russia
|
| 5 |
National Research Tomsk State University, Tomsk 634050, Russia
|
| 6 |
Boreskov Institute of Catalysis, Novosibirsk 630090, Russian Federation
|
| 7 |
Federal Center of Brain Research and Neurotechnologies, Federal Medical Biological Agency, Moscow 117513, Russia
|
| 8 |
Voevodsky Institute of Chemical Kinetics and Combustion, SB RAS, Novosibirsk 630090, Russia
|
| 9 |
Institute of Strength Physics and Materials Science, SB RAS, Tomsk 634055, Russia
|
| 10 |
Department of Physics & CICECO - Aveiro Institute of Materials, University of Aveiro, Aveiro 3810-193, Portugal
|
| 11 |
National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, Sichuan, China
|
| 12 |
Innovation Center for Textile Science and Technology, College of Textiles, Donghua University, Shanghai 201620, China
|
| 13 |
Institute of Molecular and Cellular Biology SB RAS, 630090 Novosibirsk, Russia
|
|
Funding (8)
|
1
|
The Ministry of Education and Science of the Russian Federation
|
14.621.21.0015 (RFMEFI62117X0015)
|
|
2
|
Foundation for Science and Technology
|
UIDB/50011/2020
|
|
3
|
Foundation for Science and Technology
|
UIDP/50011/2020
|
|
4
|
Ministry of Science and Higher Education of the Russian Federation
|
075-15-2021-588
|
|
5
|
Russian Science Foundation
|
24-43-00171 (123122100091-4)
|
|
6
|
Ministry of Science and Higher Education of the Russian Federation
|
FWNR-2022-0015
|
|
7
|
Ministry of Science and Higher Education of the Russian Federation
|
FWNR-2025-0019
|
|
8
|
National Natural Science Foundation of China
|
32361133548
|
Targeted therapeutic delivery to specific regions of the central nervous system (CNS) is a promising approach for treating localized pathologies such as neuropathic pain or viral infections. The systemic administration of drugs is often inefficient, as it distributes medication throughout the body, including non-targeted CNS areas, rather than concentrating it in the affected neural tissues. Leveraging axonal transport for targeted drug delivery could enable precise therapeutic interventions, such as antiviral, antineuropathic, or regenerative treatments, selectively directed to specific ganglia or CNS cells. In this study, we developed a novel strategy using magnetoelectric (ME) nanotransducers based on the core-shell MnFe2O4@Ba0.85Ca0.15Zr0.1Ti0.9O3 nanoparticles (MFO@BCZT NPs), which exhibit an exceptionally high ME response (12.2 × 105 mV·cm−1·Oe−1), to facilitated axonal transport of cargoes from the nasal cavity to the brain by a low-intensity alternating magnetic field (0–50 Hz, 0–30 mT). Firstly, in vitro experiments demonstrated that MFO@BCZT NPs efficiently activated voltage-gated calcium channels in primary neurons under safe magnetic stimulation. Ex vivo studies further confirmed enhanced cellular uptake of MFO@BCZT NPs and their ability for effective wireless stimulation of mouse hippocampal slices. Finally, in vivo experiments revealed significant ME-mediated improvement of axonal transport of BSA-Cy7 from nasal cavity into the mouse brain using MFO@BCZT NPs. This study establishes a non-invasive ME nanoplatform for spatiotemporally controlled neuronal logistics, offering a transformative approach for targeted therapeutic delivery to CNS.