Diclofenac-Enriched Polyurethane-Based Scaffolds Produced by Electrospinning: Drug Release, Cytotoxicity, and Anti-Inflammatory Effect Full article
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Biomedical Engineering Communications
ISSN: 2815-9063 |
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| Output data | Year: 2026, Volume: 5, Number: 1, Article number : 4, Pages count : 9 DOI: 10.53388/BMEC2026004 | ||||
| Tags | diclofenac; electrospinning; drug-enriched scaffolds; polyurethane; cardiovascular tissue engineering; vascular grafts and stents; drug delivery | ||||
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| Affiliations |
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Funding (1)
| 1 | Ministry of Science and Higher Education of the Russian Federation | FWGN-2025-0017 (125012300656-5)(075-03-2025-069) |
Abstract:
The development of materials for cardiovascular surgery that would improve the effectiveness of surgical interventions remains an important task. Surgical intervention during the implantation of vascular prostheses and stents, and the body’s reaction to artificial materials, could lead to chronic inflammation, a local increase in the concentration of proinflammatory factors, and stimulation of unwanted tissue growth. The introduction of nonsteroidal anti-inflammatory drugs into implantable devices could be used to obtain vascular implants that do not induce inflammation and do not induce neointimal tissue outgrowth. Methods: The scaffolds were made by electrospinning from mixtures of polyurethane (PU) with diclofenac (DF). The kinetics of DF release from the scaffolds composed of 3%PU/10%HSA/3%DMSO/DF and 3%PU/DF were studied. The biocompatibility and anti-inflammatory effects of the obtained scaffolds on human gingival fibroblasts and umbilical vein endothelial cells were studied. Results: Both types of scaffolds are characterized by fast DF release. The viability of cells cultured on scaffolds is 2 times worse than that of cells cultured on plastic. The level of the proinflammatory cytokine IL-6 in the culture medium of cells cultured on DF-containing scaffolds was lower than that of cells cultured on scaffolds without DF. Conclusion: The introduction of DF into scaffolds minimizes the inflammation caused by cell reactions to an artificial material.
Cite:
Nazarkina Z.K.
, Chelobanov B.P.
, Kvon R.I.
, Laktionov P.P.
Diclofenac-Enriched Polyurethane-Based Scaffolds Produced by Electrospinning: Drug Release, Cytotoxicity, and Anti-Inflammatory Effect
Biomedical Engineering Communications. 2026. V.5. N1. 4 :1-9. DOI: 10.53388/BMEC2026004 Scopus OpenAlex AN
Diclofenac-Enriched Polyurethane-Based Scaffolds Produced by Electrospinning: Drug Release, Cytotoxicity, and Anti-Inflammatory Effect
Biomedical Engineering Communications. 2026. V.5. N1. 4 :1-9. DOI: 10.53388/BMEC2026004 Scopus OpenAlex AN
Dates:
| Submitted: | Jun 6, 2025 |
| Accepted: | Jul 21, 2025 |
| Published online: | Jul 24, 2025 |
| Published print: | Jan 1, 2026 |
Identifiers:
| ≡ Scopus: | 2-s2.0-105026101835 |
| ≡ OpenAlex: | W4412648578 |
| ≡ Chemical Abstracts: | 2026:28900 |
Citing:
| ≡ Scopus | 0 | Сбор данных от 15.02.2026 |
| ≡ OpenAlex | 0 | Сбор данных от 15.02.2026 |