Synthesis of Unsaturated Secondary Amines by Direct Reductive Amination of Aliphatic Aldehydes with Nitroarenes over Au/Al2O3 Catalyst in a Continuous Flow Mode
Научная публикация
| Общее |
Язык:
Английский,
Жанр:
Статья (Full article),
Статус опубликования:
Опубликована,
Оригинальность:
Оригинальная
|
| Журнал |
RSC Advances
ISSN: 2046-2069
|
| Вых. Данные |
Год: 2016,
Том: 6,
Номер: 91,
Страницы: 88366 - 88372
Страниц
: 7
DOI:
10.1039/C6RA20904A
|
| Авторы |
Nuzhdin A.L.
1
,
Artyukha E.A.
1,2
,
Bukhtiyarova G.A.
1
,
Zaytsev S.Yu.
3
,
Plyusnin P.E.
2,3
,
Shubin Yu.V.
2,3
,
Bukhtiyarov V.I.
1,2
|
| Организации |
| 1 |
Boreskov Institute of Catalysis, SB RAS, Lavrentieva Ave. 5, Novosibirsk, 630090, Russia
|
| 2 |
Novosibirsk State University, Pirogova Str. 2, Novosibirsk, 630090 Russia
|
| 3 |
Nikolaev Institute of Inorganic Chemistry, SB RAS, Lavrentieva Ave. 3, Novosibirsk, 630090 Russia
|
|
Информация о финансировании (1)
|
1
|
Федеральное агентство научных организаций России
|
V.45.3.7.
|
A series of unsaturated secondary amines was successfully synthesized by direct reductive amination of
aliphatic aldehydes with nitroarenes over a 2.5% Au/Al2O3 catalyst in a continuous flow reactor using
molecular hydrogen as a reducing agent. In most cases, the targeted secondary amines were obtained in
good to excellent yields. Interestingly, the hydrogenation of C]C group is practically absent in both
initial aldehydes and secondary amines under the reaction conditions. It was found that the introduction
of electron-donating substituents in the para- and meta-position of nitrobenzenes increased the yield of
secondary amine, while in the case of nitrobenzenes with electron-withdrawing substituents or
electron-donating substituents in the ortho-position a decrease in the yield of the target product was
observed.