Aqueous, Heterogeneous para-Hydrogen-Induced 15N Polarization
Научная публикация
| Общее |
Язык:
Английский,
Жанр:
Статья (Full article),
Статус опубликования:
Опубликована,
Оригинальность:
Оригинальная
|
| Журнал |
The Journal of Physical Chemistry C
ISSN: 1932-7447
, E-ISSN: 1932-7455
|
| Вых. Данные |
Год: 2017,
Том: 121,
Номер: 28,
Страницы: 15304-15309
Страниц
: 6
DOI:
10.1021/acs.jpcc.7b05912
|
| Авторы |
Bales Liana B.
1
,
Kovtunov Kirill V.
2,3
,
Barskiy Danila A.
4
,
Shchepin Roman V.
4
,
Coffey Aaron M.
4
,
Kovtunova Larisa M.
3,5
,
Bukhtiyarov Andrey V.
5
,
Feldman Matthew A.
4
,
Bukhtiyarov Valerii I.
3,5
,
Chekmenev Eduard Y.
6,7,4
,
Koptyug Igor V.
2,3
,
Goodson Boyd M.
1,8
|
| Организации |
| 1 |
Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, Illinois 62901, United States
|
| 2 |
International Tomography Center SB RAS, Novosibirsk 630090, Russia
|
| 3 |
Novosibirsk State University, Novosibirsk 630090, Russia
|
| 4 |
Vanderbilt Institute of Imaging Science (VUIIS), Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States
|
| 5 |
Boreskov Institute of Catalysis SB RAS, Novosibirsk 630090, Russia
|
| 6 |
Department of Biomedical Engineering and Physics, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee 37232, United
States
|
| 7 |
Russian Academy of Sciences, Moscow 119991, Russia
|
| 8 |
Materials Technology Center, Southern Illinois University, Carbondale, Illinois 62901, United States
|
|
Информация о финансировании (17)
|
1
|
Российский научный фонд
|
14-23-00146
|
|
2
|
Российский фонд фундаментальных исследований
|
16-03-00407
|
|
3
|
Министерство образования и науки Российской Федерации
|
МК-4498.2016.3
|
|
4
|
National Institutes of Health
|
1R21EB018014
|
|
5
|
National Institutes of Health
|
1R21EB020323
|
|
6
|
National Science Foundation
|
CHE-1416268
|
|
7
|
United States Department of Defense
|
W81XWH-12-1-0159/BC112431
|
|
8
|
United States Department of Defense
|
W81XWH-15-1-0271
|
|
9
|
Федеральное агентство научных организаций России
|
0303-2015-0010
|
|
10
|
National Science Foundation
|
CHE-1416432
|
|
11
|
National Institutes of Health
|
1F32EB021840
|
|
12
|
United States Department of Defense
|
W81XWH-15-1-0272
|
|
13
|
Федеральное агентство научных организаций России
|
V.44.1.8. (0333-2016-0001)
|
|
14
|
Российский фонд фундаментальных исследований
|
17-54-33037
|
|
15
|
National Science Foundation
|
REU DMR-1461255
|
|
16
|
National Institutes of Health
|
5R00CA134749
|
|
17
|
National Institutes of Health
|
5R00CA134749-02S1
|
The successful transfer of para-hydrogen-induced polarization to 15N spins using heterogeneous catalysts in aqueous solutions was demonstrated. Hydrogenation of a synthesized unsaturated 15N-labeled precursor (neurine) with parahydrogen (p-H2) over Rh/TiO2 heterogeneous catalysts yielded a hyperpolarized structural analogue of choline. As a result, 15N polarization enhancements of over 2 orders of magnitude were achieved for the 15N-labeled ethyltrimethylammonium ion product in deuterated water at elevated temperatures. Enhanced 15N NMR spectra were successfully acquired at 9.4 and 0.05 T. Importantly, long hyperpolarization lifetimes were observed at 9.4 T, with a 15N T1 of ∼6 min for the product molecules, and the T1 of the deuterated form exceeded 8 min. Taken together, these results show that this approach for generating hyperpolarized species with extended lifetimes in aqueous, biologically compatible solutions is promising for various biomedical applications.