High-Resolution 3D Proton MRI of Hyperpolarized Gas Enabled by Parahydrogen and Rh/TiO2 Heterogeneous Catalyst
Научная публикация
| Общее |
Язык:
Английский,
Жанр:
Статья (Full article),
Статус опубликования:
Опубликована,
Оригинальность:
Оригинальная
|
| Журнал |
Chemistry - A European Journal
ISSN: 0947-6539
, E-ISSN: 1521-3765
|
| Вых. Данные |
Год: 2014,
Том: 20,
Номер: 37,
Страницы: 11636-11639
Страниц
: 4
DOI:
10.1002/chem.201403604
|
| Ключевые слова |
heterogeneous catalysis, hyperpolarized gas, magnetic resonance imaging, parahydrogen, supported catalysts |
| Авторы |
Kovtunov Kirill V.
1,2
,
Barskiy Danila A.
1,2
,
Coffey Aaron M.
3,4,5,6
,
Truong Milton L.
3,4,5,6
,
Salnikov Oleg G.
1,2
,
Khudorozhkov Alexander K.
7
,
Inozemtseva Elizaveta A.
7
,
Prosvirin Igor P.
7
,
Bukhtiyarov Valery I.
7
,
Waddell Kevin W.
3,4,5,6
,
Chekmenev Eduard Y.
3,4,5,6
,
Koptyug Igor V.
1,2
|
| Организации |
| 1 |
Laboratory of Magnetic Resonance Microimaging , International Tomography Center, SB RAS, 3A Institutskaya St., Novosibirsk 630090 (Russia)
|
| 2 |
Novosibirsk State University, 2 Pirogova St., Novosibirsk 630090 (Russia)
|
| 3 |
Institute of Imaging Science, Department of Radiology, Nashville, Tennessee, 37232-2310 (USA)
|
| 4 |
Department of Biomedical Engineering, Nashville, Tennessee, 37232-2310 (USA)
|
| 5 |
Department of Physics and Astronomy, Nashville, Tennessee, 37232-2310 (USA)
|
| 6 |
Department of Biochemistry, Nashville, Tennessee, 37232-2310 (USA)
|
| 7 |
Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., Novosibirsk 630090 (Russia)
|
|
Информация о финансировании (14)
|
1
|
Федеральное агентство научных организаций России
|
V.45.3.2.
|
|
2
|
Российский фонд фундаментальных исследований
|
14-03-00374
|
|
3
|
United States Department of Defense
|
W81XWH-12-1-0159/BC112431
|
|
4
|
Президиум РАН
|
5.1.1
|
|
5
|
Российский фонд фундаментальных исследований
|
12-03-00403
|
|
6
|
Совет по грантам Президента Российской Федерации
|
МК-4391.2013.3
|
|
7
|
Президиум СО РАН
|
57
|
|
8
|
Президиум СО РАН
|
60
|
|
9
|
Президиум СО РАН
|
61
|
|
10
|
Президиум СО РАН
|
122
|
|
11
|
Российский фонд фундаментальных исследований
|
14-03-31239 (01201450183)
|
|
12
|
National Institutes of Health
|
3R00A134749-02S1
|
|
13
|
National Institutes of Health
|
5P50 CA128323-03
|
|
14
|
National Institutes of Health
|
R21 GM107947 5R00 CA134749-03
|
Several supported metal catalysts were synthesized, characterized, and tested in heterogeneous hydrogenation of propene with parahydrogen to maximize nuclear spin hyperpolarization of propane gas using parahydrogen induced polarization (PHIP). The Rh/TiO2 catalyst with a metal particle size of 1.6 nm was found to be the most active and effective in the pairwise hydrogen addition and robust, demonstrating reproducible results with multiple hydrogenation experiments and stability for ≥1.5 years. 3D (1) H magnetic resonance imaging (MRI) of 1 % hyperpolarized flowing gas with microscale spatial resolution (625×625×625 μm(3) ) and large imaging matrix (128×128×32) was demonstrated by using a preclinical 4.7 T scanner and 17.4 s imaging scan time.