The Mechanism of Interacting Biologically Active Complexes Dehydroepiandrosterone- or Tetrahydrocortisol-Apolipoprotein A-I with DNA and their Role in Enhancement of Gene Expression and Protein Biosynthesis in Hepatocytes Научная публикация
Журнал |
Current Chemical Biology
ISSN: 2212-7968 , E-ISSN: 1872-3136 |
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Вых. Данные | Год: 2011, Том: 5, Номер: 1, Страницы: 9-16 Страниц : 8 DOI: 10.2174/2212796811105010009 | ||
Ключевые слова | Apolipoprotein AI, Dehydroepiandrosterone, DNA structure, Protein biosynthesis, Tetrahydrocortisol | ||
Авторы |
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Организации |
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Реферат:
Dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEAS) and tetrahydrocortisol (THC) with apolipoprotein A-I form the biologically active complexes able to interact specifically with eukaryotic DNA. This conjugate is highly cooperative and results in local splitting of DNA. Specific binding sites of steroid-apoA-I complexes are the (GCC/GGC)n sequences. At the sites of splitting, single-stranded regions sensitized to the action of S1-nuclease form. These regions are irregularly distributed over DNA. The formation of single-stranded DNA regions can promote the interaction with RNA-polymerase. Formation of the biologically active THC (DHEA)-apoA-I complexes is related with resident macrophages having 5α- and 5 β-reductase activity. These complexes greatly enhance the rate of protein biosynthesis in hepatocytes. The cortisol-apoA-I complex does not show such effect. So, the reduced forms of fascicular zone and reticular cortex adrenal zone hormones have synergism of action toward gene expression and protein biosynthesis. The intensification of tissues regeneration during the stress period as a result of given mechanism is discussed.
Библиографическая ссылка:
Panin L.
, Gimautdinova O.
, Kuznetsov P.
, Tuzikov F.
The Mechanism of Interacting Biologically Active Complexes Dehydroepiandrosterone- or Tetrahydrocortisol-Apolipoprotein A-I with DNA and their Role in Enhancement of Gene Expression and Protein Biosynthesis in Hepatocytes
Current Chemical Biology. 2011. V.5. N1. P.9-16. DOI: 10.2174/2212796811105010009 Scopus РИНЦ
The Mechanism of Interacting Biologically Active Complexes Dehydroepiandrosterone- or Tetrahydrocortisol-Apolipoprotein A-I with DNA and their Role in Enhancement of Gene Expression and Protein Biosynthesis in Hepatocytes
Current Chemical Biology. 2011. V.5. N1. P.9-16. DOI: 10.2174/2212796811105010009 Scopus РИНЦ
Даты:
Поступила в редакцию: | 25 мар. 2010 г. |
Принята к публикации: | 23 авг. 2010 г. |
Опубликована в печати: | 1 янв. 2011 г. |
Идентификаторы БД:
Scopus | 2-s2.0-78951474609 |
РИНЦ | 17819190 |
Chemical Abstracts | 2011:470351 |
Chemical Abstracts (print) | 158:67044 |
OpenAlex | W2322559900 |