A Generic 3D Kinetic Model of Gene Expression Review
Journal |
Central European Journal of Physics
ISSN: 1895-1082 , E-ISSN: 1644-3608 |
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Output data | Year: 2012, Volume: 10, Number: 2, Pages: 533-537 Pages count : 5 DOI: 10.2478/s11534-012-0011-5 | ||||
Tags | gene transcription, mRNA and protein diffusion and degradation, mRNA synthesis, mRNA translation, subcellular processes | ||||
Authors |
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Affiliations |
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Abstract:
Recent experiments show that mRNAs and proteins can be localized both in prokaryotic and eukaryotic cells. To describe such situations, I present a 3D mean-field kinetic model aimed primarily at gene expression in prokaryotic cells, including the formation of mRNA, its translation into protein, and slow diffusion of these species. Under steady-state conditions, the mRNA and protein spatial distribution is described by simple exponential functions. The protein concentration near the gene transcribed into mRNA is shown to depend on the protein and mRNA diffusion coefficients and degradation rate constants.
Cite:
Zhdanov V.P.
A Generic 3D Kinetic Model of Gene Expression
Central European Journal of Physics. 2012. V.10. N2. P.533-537. DOI: 10.2478/s11534-012-0011-5 WOS Scopus РИНЦ
A Generic 3D Kinetic Model of Gene Expression
Central European Journal of Physics. 2012. V.10. N2. P.533-537. DOI: 10.2478/s11534-012-0011-5 WOS Scopus РИНЦ
Dates:
Submitted: | Dec 21, 2011 |
Accepted: | Jan 21, 2012 |
Published online: | Mar 31, 2012 |
Published print: | Apr 1, 2012 |
Identifiers:
Web of science | WOS:000302285700018 |
Scopus | 2-s2.0-84859213899 |
Elibrary | 17981623 |
Chemical Abstracts | 2012:468153 |
Chemical Abstracts (print) | 158:67196 |
OpenAlex | W2056661723 |