Small-Angle Neutron Scattering from Polymer Hydrogels with Memory Effect for Medicine Immobilization Full article
Journal |
Crystallography Reports
ISSN: 1063-7745 , E-ISSN: 1562-689X |
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Output data | Year: 2011, Volume: 56, Number: 7, Pages: 1114-1117 Pages count : 9 DOI: 10.1134/S1063774511070170 | ||||||
Tags | DRUG-DELIVERY; CONTACT-LENSES; RELEASE | ||||||
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Abstract:
Hydrogels synthesized based on cross-linked copolymers of 2-hydroxyethyl methacrylate and functional monomers (acrylic acid or dimethylaminoethyl methacrylate), having a memory effect with respect to target medicine (cefazolin), have been investigated by small-angle neutron scattering. The hydrogels are found to have a two-level structural organization: large (up to 100 nm) aggregates filled with network cells (4–7 nm in size). The structural differences in the anionic, cationic, and amphiphilic hydrogels and the relationship between their structure and the ability of hydrogels to absorb moisture are shown. A relationship between the memory effect during cefazolin immobilization and the internal structure of hydrogels, depending on their composition and type of functional groups, is established.
Cite:
Kulvelis Y.V.
, Lebedev V.T.
, Trunov V.A.
, Pavlyuchenko V.N.
, Ivanchev S.S.
, Primachenko O.N.
, Khaikin S.Y.
Small-Angle Neutron Scattering from Polymer Hydrogels with Memory Effect for Medicine Immobilization
Crystallography Reports. 2011. V.56. N7. P.1114-1117. DOI: 10.1134/S1063774511070170 WOS Scopus РИНЦ
Small-Angle Neutron Scattering from Polymer Hydrogels with Memory Effect for Medicine Immobilization
Crystallography Reports. 2011. V.56. N7. P.1114-1117. DOI: 10.1134/S1063774511070170 WOS Scopus РИНЦ
Dates:
Submitted: | Dec 16, 2010 |
Published online: | Nov 19, 2011 |
Published print: | Dec 1, 2011 |
Identifiers:
Web of science | WOS:000297372800007 |
Scopus | 2-s2.0-84856726288 |
Elibrary | 18034949 |
Chemical Abstracts | 2011:1488233 |
Chemical Abstracts (print) | 157:176825 |
OpenAlex | W2071079403 |