Influence of Multi-Walled Carbon Nanotubes on the Cognitive Abilities of Wistar Rats | Sciact - CRIS-system of Boreskov Institute of Catalysis

Influence of Multi-Walled Carbon Nanotubes on the Cognitive Abilities of Wistar Rats Full article

Journal

Experimental and Therapeutic Medicine
ISSN: 1792-0981 , E-ISSN: 1792-1015

Output data

Year: 2016, Volume: 12, Number: 3, Pages: 1311-1318 Pages count : 8 DOI: 10.3892/etm.2016.3495

Tags

Cognitive, Multi-walled carbon nanotubes, Stress, Wistar rats

Authors

Sayapina Nina V. ¹ , Sergievich Alexander A. ² , Kuznetsov Vladimir L. ³ , Chaika Vladimir V. ² , Lisitskaya Irina G. ² , Khoroshikh Pavel P. ⁴ , Batalova Tatyana A. ¹ , Tsarouhas Kostas ⁵ , Spandidos Demetrios ⁶ , Tsatsakis Aristidis M. ^2,7 , Fenga Concettina ⁸ , Golokhvast Kirill S. ²

Affiliations

1	Department of Physiology, Amur State Medical Academy, 675000 Blagoveshchensk
2	Scientific Educational Center of Nanotechnology, Far Eastern Federal University, 690950 Vladivostok
3	Group of Surface Compounds Synthesis, Boreskov Institute of Catalysis SB RAS, 630090 Novosibirsk
4	Technical Institute, North‑Eastern Federal University, 678962 Nerungri, Russia
5	Cardiology Department, University Hospital of Larissa, 41110 Thessaly
6	Laboratory of Clinical Virology, University of Crete, 74100 Heraklion, Greece
7	Department of Forensic Sciences and Toxicology, Medical School, University of Crete, 74100 Heraklion, Greece
8	Department of Occupational Medicine, University of Messina, 98166 Messina, Italy

Funding (1)

Russian Science Foundation

15-14-20032

Studies of the neurobehavioral effects of carbon nanomaterials, particularly those of multi‑walled carbon nanotubes (MWCNTs), have concentrated on cognitive effects, but data are scarce. The aim of this study was to assess the influence of MWCNTs on a number of higher nervous system functions of Wistar rats. For a period of 10 days, two experimental groups were fed with MWCNTs of different diameters (MWCNT-1 group, 8‑10 nm; MWCNT-2 group, 18‑20 nm) once a day at a dosage of 500 mg/kg. In the open‑field test, reductions of integral indications of researching activity were observed for the two MWCNT-treated groups, with a parallel significant (P<0.01) increase in stress levels for these groups compared with the untreated control group. In the elevated plus‑maze test, integral indices of researching activity in the MWCNT-1 and MWCNT-2 groups reduced by day 10 by 51 and 62%, respectively, while rat stress levels remained relatively unchanged. In the universal problem solving box test, reductions in motivation and energy indices of researching activity were observed in the two experimental groups. Searching activity in the MWCNT‑1 group by day 3 was reduced by 50% (P<0.01) and in the MWCNT‑2 group the relevant reduction reached 11.2%. By day 10, the reduction compared with controls, was 64% (P<0.01) and 58% (P<0.01) for the MWCNT‑1 and MWCNT‑2 groups, respectively. In conclusion, a series of specific tests demonstrated that MWCNT‑treated rats experienced a significant reduction of some of their cognitive abilities, a disturbing and worrying finding, taking into consideration the continuing and accelerating use of carbon nanotubes in medicine and science.

Sayapina N.V. , Sergievich A.A. , Kuznetsov V.L. , Chaika V.V. , Lisitskaya I.G. , Khoroshikh P.P. , Batalova T.A. , Tsarouhas K. , Spandidos D. , Tsatsakis A.M. , Fenga C. , Golokhvast K.S.
Influence of Multi-Walled Carbon Nanotubes on the Cognitive Abilities of Wistar Rats

Experimental and Therapeutic Medicine. 2016. V.12. N3. P.1311-1318. DOI: 10.3892/etm.2016.3495 WOS Scopus РИНЦ AN PMID OpenAlex

Full text from publisher

Submitted:	Feb 10, 2016
Accepted:	May 17, 2016
Published online:	Jul 1, 2016
Published print:	Sep 1, 2016

Web of science:	WOS:000382446000010
Scopus:	2-s2.0-84980383712
Elibrary:	27122657
Chemical Abstracts:	2017:1550359
PMID:	27588053
OpenAlex:	W2471459408

DB	Citing
Web of science	10
Scopus	11
OpenAlex	13