Sciact
  • EN
  • RU

Cytopathic Effects of X-Ray Irradiation and MnO Nanoparticles on Human Glioblastoma (U87) Научная публикация

Конференция The International Conference "Synchrotron and Free electron laser Radiation: generation and application"
04-07 июл. 2016 , Novosibirsk
Журнал Physics Procedia
ISSN: 1875-3892
Вых. Данные Год: 2016, Том: 84, Страницы: 252-255 Страниц : 4 DOI: 10.1016/j.phpro.2016.11.043
Ключевые слова glioblastoma, nanoparticles, radiation therapy
Авторы Kuper K.E. 1 , Zavjalov E.L. 2 , Razumov I.A. 2 , Romaschenko A.V. 2 , Stupak A.S. 2 , Troicky S.Yu. 3 , Goldenberg B.G. 1 , Legkodymov A.G. 1 , Lemzyakov A.A. 1 , Moshkin M.P. 2
Организации
1 Budker Institute of Nuclear physics, SB RAS, Novosibirsk, 630090, Russiab
2 Institute of Cytology and Genetics, SB RAS, Novosibirsk, 630090, Russia
3 Boreskov Institute of Catalysis, SB RAS, Novosibirsk, 630090, Russia

Информация о финансировании (1)

1 Российский научный фонд 14-50-00080

Реферат: Glioblastoma is a leader among the most malignant brain tumors with the average lifespan of patients around 9-12 months. For prevention and treatment of neuropathology, a variety of therapeutic and surgical approaches are being developed and improved, including radiation and chemical therapy methods. In our work, we investigated cytopathic effect of X-ray irradiation with application of metal oxides nanoparticles such as manganese oxide (MnO) on U87 human glioblastoma cells. We used the X-ray irradiation dose of 0.5, 4, 40 and 100 Gy in combination with nanoparticles at the concentration of 0.5 ng/ml. The irradiation of glioma cell was carried out at the synchrotron radiation source VEPP-4. After cells treatments with nanoparticles for about 24 h and radiation the results were assessed by MTT assay test with 106/ml cells densities. We demonstrate that preincubation of the glioblastoma cell lines U87 with MnO nanoparticles allows reducing dose of irradiation. This combination of nanoparticles and X-ray irradiation provides new possibilities for the treatment of brain tumors.
Библиографическая ссылка: Kuper K.E. , Zavjalov E.L. , Razumov I.A. , Romaschenko A.V. , Stupak A.S. , Troicky S.Y. , Goldenberg B.G. , Legkodymov A.G. , Lemzyakov A.A. , Moshkin M.P.
Cytopathic Effects of X-Ray Irradiation and MnO Nanoparticles on Human Glioblastoma (U87)
Physics Procedia. 2016. V.84. P.252-255. DOI: 10.1016/j.phpro.2016.11.043 WOS Scopus РИНЦ CAPlus OpenAlex
Файлы: Полный текст от издателя
Даты:
Опубликована в печати: 1 янв. 2016 г.
Опубликована online: 12 дек. 2016 г.
Идентификаторы БД:
Web of science: WOS:000392696400041
Scopus: 2-s2.0-85016316777
РИНЦ: 29500904
Chemical Abstracts: 2016:2089570
OpenAlex: W2567228315
Цитирование в БД:
БД Цитирований
Web of science 8
Scopus 8
РИНЦ 11
OpenAlex 9
Альметрики: