Cytopathic Effects of X-Ray Irradiation and MnO Nanoparticles on Human Glioblastoma (U87) Full article
| Conference |
The International Conference "Synchrotron and Free electron laser Radiation: generation and application" 04-07 Jul 2016 , Novosibirsk |
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| Journal |
Physics Procedia
ISSN: 1875-3892 |
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| Output data | Year: 2016, Volume: 84, Pages: 252-255 Pages count : 4 DOI: 10.1016/j.phpro.2016.11.043 | ||||||
| Tags | glioblastoma, nanoparticles, radiation therapy | ||||||
| Authors |
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| Affiliations |
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Funding (1)
| 1 | Russian Science Foundation | 14-50-00080 |
Abstract:
Glioblastoma is a leader among the most malignant brain tumors with the average lifespan of patients around 9-12 months. For prevention and treatment of neuropathology, a variety of therapeutic and surgical approaches are being developed and improved, including radiation and chemical therapy methods. In our work, we investigated cytopathic effect of X-ray irradiation with application of metal oxides nanoparticles such as manganese oxide (MnO) on U87 human glioblastoma cells. We used the X-ray irradiation dose of 0.5, 4, 40 and 100 Gy in combination with nanoparticles at the concentration of 0.5 ng/ml. The irradiation of glioma cell was carried out at the synchrotron radiation source VEPP-4. After cells treatments with nanoparticles for about 24 h and radiation the results were assessed by MTT assay test with 106/ml cells densities. We demonstrate that preincubation of the glioblastoma cell lines U87 with MnO nanoparticles allows reducing dose of irradiation. This combination of nanoparticles and X-ray irradiation provides new possibilities for the treatment of brain tumors.
Cite:
Kuper K.E.
, Zavjalov E.L.
, Razumov I.A.
, Romaschenko A.V.
, Stupak A.S.
, Troicky S.Y.
, Goldenberg B.G.
, Legkodymov A.G.
, Lemzyakov A.A.
, Moshkin M.P.
Cytopathic Effects of X-Ray Irradiation and MnO Nanoparticles on Human Glioblastoma (U87)
Physics Procedia. 2016.
V.84. P.252-255. DOI: 10.1016/j.phpro.2016.11.043
WOS
Scopus
РИНЦ
AN
OpenAlex
Cytopathic Effects of X-Ray Irradiation and MnO Nanoparticles on Human Glioblastoma (U87)
Physics Procedia. 2016.
V.84. P.252-255. DOI: 10.1016/j.phpro.2016.11.043
WOS
Scopus
РИНЦ
AN
OpenAlex
Files:
Full text from publisher
Dates:
| Published print: | Jan 1, 2016 |
| Published online: | Dec 12, 2016 |
Identifiers:
| Web of science: | WOS:000392696400041 |
| Scopus: | 2-s2.0-85016316777 |
| Elibrary: | 29500904 |
| Chemical Abstracts: | 2016:2089570 |
| OpenAlex: | W2567228315 |