Aqueous, Heterogeneous para-Hydrogen-Induced 15N Polarization | Sciact - CRIS-система Института катализа

Aqueous, Heterogeneous para-Hydrogen-Induced 15N Polarization Научная публикация

Журнал

The Journal of Physical Chemistry C
ISSN: 1932-7447 , E-ISSN: 1932-7455

Вых. Данные

Год: 2017, Том: 121, Номер: 28, Страницы: 15304-15309 Страниц : 6 DOI: 10.1021/acs.jpcc.7b05912

Ключевые слова

Catalysts; Deuterium; Hydrogen; Medical applications; Nuclear magnetic resonance spectroscopy; Solutions

Авторы

Bales Liana B. ¹ , Kovtunov Kirill V. ^2,3 , Barskiy Danila A. ⁴ , Shchepin Roman V. ⁴ , Coffey Aaron M. ⁴ , Kovtunova Larisa M. ^3,5 , Bukhtiyarov Andrey V. ⁵ , Feldman Matthew A. ⁴ , Bukhtiyarov Valerii I. ^3,5 , Chekmenev Eduard Y. ^6,7,4 , Koptyug Igor V. ^2,3 , Goodson Boyd M. ^1,8

Организации

1	Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, Illinois 62901, United States
2	International Tomography Center SB RAS, Novosibirsk 630090, Russia
3	Novosibirsk State University, Novosibirsk 630090, Russia
4	Vanderbilt Institute of Imaging Science (VUIIS), Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States
5	Boreskov Institute of Catalysis SB RAS, Novosibirsk 630090, Russia
6	Department of Biomedical Engineering and Physics, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee 37232, United States
7	Russian Academy of Sciences, Moscow 119991, Russia
8	Materials Technology Center, Southern Illinois University, Carbondale, Illinois 62901, United States

Информация о финансировании (17)

1	Российский фонд фундаментальных исследований	17-54-33037
2	Федеральное агентство научных организаций России	V.44.1.8. (0333-2016-0001)
3	National Science Foundation	CHE-1416432
4	United States Department of Defense	W81XWH-12-1-0159/BC112431
5	National Science Foundation	CHE-1416268
6	Министерство образования и науки Российской Федерации	МК-4498.2016.3
7	Российский фонд фундаментальных исследований	16-03-00407
8	Федеральное агентство научных организаций России	0303-2015-0010
9	Российский научный фонд	14-23-00146
10	National Institutes of Health	1R21EB018014
11	National Institutes of Health	1R21EB020323
12	United States Department of Defense	W81XWH-15-1-0271
13	National Institutes of Health	1F32EB021840
14	United States Department of Defense	W81XWH-15-1-0272
15	National Science Foundation	REU DMR-1461255
16	National Institutes of Health	5R00CA134749
17	National Institutes of Health	5R00CA134749-02S1

The successful transfer of para-hydrogen-induced polarization to 15N spins using heterogeneous catalysts in aqueous solutions was demonstrated. Hydrogenation of a synthesized unsaturated 15N-labeled precursor (neurine) with parahydrogen (p-H2) over Rh/TiO2 heterogeneous catalysts yielded a hyperpolarized structural analogue of choline. As a result, 15N polarization enhancements of over 2 orders of magnitude were achieved for the 15N-labeled ethyltrimethylammonium ion product in deuterated water at elevated temperatures. Enhanced 15N NMR spectra were successfully acquired at 9.4 and 0.05 T. Importantly, long hyperpolarization lifetimes were observed at 9.4 T, with a 15N T1 of ∼6 min for the product molecules, and the T1 of the deuterated form exceeded 8 min. Taken together, these results show that this approach for generating hyperpolarized species with extended lifetimes in aqueous, biologically compatible solutions is promising for various biomedical applications.

Bales L.B. , Kovtunov K.V. , Barskiy D.A. , Shchepin R.V. , Coffey A.M. , Kovtunova L.M. , Bukhtiyarov A.V. , Feldman M.A. , Bukhtiyarov V.I. , Chekmenev E.Y. , Koptyug I.V. , Goodson B.M.
Aqueous, Heterogeneous para-Hydrogen-Induced 15N Polarization

The Journal of Physical Chemistry C. 2017. V.121. N28. P.15304-15309. DOI: 10.1021/acs.jpcc.7b05912 WOS Scopus РИНЦ OpenAlex CAPlusCA PMID

Полный текст от издателя

Поступила в редакцию:	16 июн. 2017 г.
Принята к публикации:	20 июн. 2017 г.
Опубликована online:	21 июн. 2017 г.
Опубликована в печати:	20 июл. 2017 г.

≡ Web of science:	WOS:000406355700035
≡ Scopus:	2-s2.0-85025806660
≡ РИНЦ:	31063087
≡ OpenAlex:	W2691254047
≡ Chemical Abstracts:	2017:1037989
≡ Chemical Abstracts (print):	167:216716
≡ PMID (PubMed):	29238438

≡ Web of science	37	Сбор данных от 06.02.2026
≡ Scopus	39	Сбор данных от 08.02.2026
≡ РИНЦ	42	Сбор данных от 08.02.2026
≡ OpenAlex	42	Сбор данных от 08.02.2026