Aqueous, Heterogeneous para-Hydrogen-Induced 15N Polarization | Sciact - CRIS-system of Boreskov Institute of Catalysis

Aqueous, Heterogeneous para-Hydrogen-Induced 15N Polarization Full article

Journal

The Journal of Physical Chemistry C
ISSN: 1932-7447 , E-ISSN: 1932-7455

Output data

Year: 2017, Volume: 121, Number: 28, Pages: 15304-15309 Pages count : 6 DOI: 10.1021/acs.jpcc.7b05912

Tags

Catalysts; Deuterium; Hydrogen; Medical applications; Nuclear magnetic resonance spectroscopy; Solutions

Authors

Bales Liana B. ¹ , Kovtunov Kirill V. ^2,3 , Barskiy Danila A. ⁴ , Shchepin Roman V. ⁴ , Coffey Aaron M. ⁴ , Kovtunova Larisa M. ^3,5 , Bukhtiyarov Andrey V. ⁵ , Feldman Matthew A. ⁴ , Bukhtiyarov Valerii I. ^3,5 , Chekmenev Eduard Y. ^6,7,4 , Koptyug Igor V. ^2,3 , Goodson Boyd M. ^1,8

Affiliations

1	Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, Illinois 62901, United States
2	International Tomography Center SB RAS, Novosibirsk 630090, Russia
3	Novosibirsk State University, Novosibirsk 630090, Russia
4	Vanderbilt Institute of Imaging Science (VUIIS), Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States
5	Boreskov Institute of Catalysis SB RAS, Novosibirsk 630090, Russia
6	Department of Biomedical Engineering and Physics, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee 37232, United States
7	Russian Academy of Sciences, Moscow 119991, Russia
8	Materials Technology Center, Southern Illinois University, Carbondale, Illinois 62901, United States

Funding (17)

1	Russian Science Foundation	14-23-00146
2	Federal Agency for Scientific Organizations	0303-2015-0010
3	Russian Foundation for Basic Research	16-03-00407
4	The Ministry of Education and Science of the Russian Federation	МК-4498.2016.3
5	National Institutes of Health	1R21EB018014
6	National Institutes of Health	1R21EB020323
7	National Science Foundation	CHE-1416268
8	United States Department of Defense	W81XWH-12-1-0159/BC112431
9	United States Department of Defense	W81XWH-15-1-0271
10	National Science Foundation	CHE-1416432
11	National Institutes of Health	1F32EB021840
12	United States Department of Defense	W81XWH-15-1-0272
13	Federal Agency for Scientific Organizations	V.44.1.8. (0333-2016-0001)
14	Russian Foundation for Basic Research	17-54-33037
15	National Science Foundation	REU DMR-1461255
16	National Institutes of Health	5R00CA134749
17	National Institutes of Health	5R00CA134749-02S1

The successful transfer of para-hydrogen-induced polarization to 15N spins using heterogeneous catalysts in aqueous solutions was demonstrated. Hydrogenation of a synthesized unsaturated 15N-labeled precursor (neurine) with parahydrogen (p-H2) over Rh/TiO2 heterogeneous catalysts yielded a hyperpolarized structural analogue of choline. As a result, 15N polarization enhancements of over 2 orders of magnitude were achieved for the 15N-labeled ethyltrimethylammonium ion product in deuterated water at elevated temperatures. Enhanced 15N NMR spectra were successfully acquired at 9.4 and 0.05 T. Importantly, long hyperpolarization lifetimes were observed at 9.4 T, with a 15N T1 of ∼6 min for the product molecules, and the T1 of the deuterated form exceeded 8 min. Taken together, these results show that this approach for generating hyperpolarized species with extended lifetimes in aqueous, biologically compatible solutions is promising for various biomedical applications.

Bales L.B. , Kovtunov K.V. , Barskiy D.A. , Shchepin R.V. , Coffey A.M. , Kovtunova L.M. , Bukhtiyarov A.V. , Feldman M.A. , Bukhtiyarov V.I. , Chekmenev E.Y. , Koptyug I.V. , Goodson B.M.
Aqueous, Heterogeneous para-Hydrogen-Induced 15N Polarization

The Journal of Physical Chemistry C. 2017. V.121. N28. P.15304-15309. DOI: 10.1021/acs.jpcc.7b05912 WOS Scopus РИНЦ ANCAN PMID OpenAlex

Full text from publisher

Submitted:	Jun 16, 2017
Accepted:	Jun 20, 2017
Published online:	Jun 21, 2017
Published print:	Jul 20, 2017

Web of science:	WOS:000406355700035
Scopus:	2-s2.0-85025806660
Elibrary:	31063087
Chemical Abstracts:	2017:1037989
Chemical Abstracts (print):	167:216716
PMID:	29238438
OpenAlex:	W2691254047

DB	Citing
Web of science	37
Scopus	39
Elibrary	41
OpenAlex	42