The Role of Fluids in High-Pressure Polymorphism of Drugs: Different Behaviour of β-Chlorpropamide in Different Inert Gas and Liquid Media | Sciact - CRIS-система Института катализа

The Role of Fluids in High-Pressure Polymorphism of Drugs: Different Behaviour of β-Chlorpropamide in Different Inert Gas and Liquid Media Научная публикация

Журнал

RSC Advances
ISSN: 2046-2069

Вых. Данные

Год: 2016, Том: 6, Номер: 95, Страницы: 92629-92637 Страниц : 9 DOI: 10.1039/c6ra17750f

Ключевые слова

Paraffins, Ambient pressures, High pressure polymorphism, High-pressure phasis, Hydrostatic compression, Liquid media, Pentane isopentane, Inert gases

Авторы

Zakharov B.A. ^1,2 , Seryotkin Y.V. ^1,2,3 , Tumanov N.A. ^4,5 , Paliwoda D. ⁶ , Hanfland M. ⁶ , Kurnosov A.V. ⁷ , Boldyreva E.V. ¹

Организации

1	Institute of Solid State Chemistry and Mechanochemistry SB RAS, Kutateladze Str. 18, Novosibirsk, Russian Federation
2	Novosibirsk State University, Pirogova Str. 2, Novosibirsk, Russian Federation
3	V.S. Sobolev Institute of Geology and Mineralogy SB RAS Ac., Koptyuga ave. 3, Novosibirsk, Russian Federation
4	Institute of Condensed Matter and Nanosciences, Université Catholique de Louvain, Place L. Pasteur 1, Louvain-la-Neuve, Belgium
5	Université de Namur, Rue de Bruxelles 61, Namur, Belgium
6	European Synchrotron Radiation Facility, Avenue des Martyrs 71, Grenoble, France
7	Bayerisches Geoinstitut, Universität Bayreuth, Universitätsstraße 30, Bayreuth, Germany

The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1:1 pentane-isopentane mixture.

Zakharov B.A. , Seryotkin Y.V. , Tumanov N.A. , Paliwoda D. , Hanfland M. , Kurnosov A.V. , Boldyreva E.V.
The Role of Fluids in High-Pressure Polymorphism of Drugs: Different Behaviour of β-Chlorpropamide in Different Inert Gas and Liquid Media

RSC Advances. 2016. V.6. N95. P.92629-92637. DOI: 10.1039/c6ra17750f WOS Scopus РИНЦ CAPlus OpenAlex

Полный текст от издателя

Поступила в редакцию:	12 июл. 2016 г.
Принята к публикации:	21 сент. 2016 г.
Опубликована online:	21 сент. 2016 г.

Web of science:	WOS:000385389800057
Scopus:	2-s2.0-84989318889
РИНЦ:	27570815
Chemical Abstracts:	2016:1539080
OpenAlex:	W2523564795

БД	Цитирований
Web of science	29
Scopus	28
OpenAlex	25