The Role of Fluids in High-Pressure Polymorphism of Drugs: Different Behaviour of β-Chlorpropamide in Different Inert Gas and Liquid Media | Sciact - CRIS-system of Boreskov Institute of Catalysis

The Role of Fluids in High-Pressure Polymorphism of Drugs: Different Behaviour of β-Chlorpropamide in Different Inert Gas and Liquid Media Full article

Journal

RSC Advances
ISSN: 2046-2069

Output data

Year: 2016, Volume: 6, Number: 95, Pages: 92629-92637 Pages count : 9 DOI: 10.1039/c6ra17750f

Tags

Paraffins, Ambient pressures, High pressure polymorphism, High-pressure phasis, Hydrostatic compression, Liquid media, Pentane isopentane, Inert gases

Authors

Zakharov B.A. ^1,2 , Seryotkin Y.V. ^1,2,3 , Tumanov N.A. ^4,5 , Paliwoda D. ⁶ , Hanfland M. ⁶ , Kurnosov A.V. ⁷ , Boldyreva E.V. ¹

Affiliations

1	Institute of Solid State Chemistry and Mechanochemistry SB RAS, Kutateladze Str. 18, Novosibirsk, Russian Federation
2	Novosibirsk State University, Pirogova Str. 2, Novosibirsk, Russian Federation
3	V.S. Sobolev Institute of Geology and Mineralogy SB RAS Ac., Koptyuga ave. 3, Novosibirsk, Russian Federation
4	Institute of Condensed Matter and Nanosciences, Université Catholique de Louvain, Place L. Pasteur 1, Louvain-la-Neuve, Belgium
5	Université de Namur, Rue de Bruxelles 61, Namur, Belgium
6	European Synchrotron Radiation Facility, Avenue des Martyrs 71, Grenoble, France
7	Bayerisches Geoinstitut, Universität Bayreuth, Universitätsstraße 30, Bayreuth, Germany

The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1:1 pentane-isopentane mixture.

Zakharov B.A. , Seryotkin Y.V. , Tumanov N.A. , Paliwoda D. , Hanfland M. , Kurnosov A.V. , Boldyreva E.V.
The Role of Fluids in High-Pressure Polymorphism of Drugs: Different Behaviour of β-Chlorpropamide in Different Inert Gas and Liquid Media

RSC Advances. 2016. V.6. N95. P.92629-92637. DOI: 10.1039/c6ra17750f WOS Scopus РИНЦ AN OpenAlex

Full text from publisher

Submitted:	Jul 12, 2016
Accepted:	Sep 21, 2016
Published online:	Sep 21, 2016

Web of science:	WOS:000385389800057
Scopus:	2-s2.0-84989318889
Elibrary:	27570815
Chemical Abstracts:	2016:1539080
OpenAlex:	W2523564795

DB	Citing
Web of science	26
Scopus	28
OpenAlex	25