A New Polymorph of Metacetamol | Sciact - CRIS-система Института катализа

A New Polymorph of Metacetamol Научная публикация

Журнал

CrystEngComm
ISSN: 1466-8033

Вых. Данные

Год: 2015, Том: 17, Номер: 32, Страницы: 6183-6192 Страниц : 10 DOI: 10.1039/c5ce00910c

Ключевые слова

INDUCED LIVER-INJURY; NONHEPATOTOXIC REGIOISOMER; ORTHORHOMBIC PARACETAMOL; PARA-HYDROXYACETANILIDE; HIGH-PRESSURE; MOUSE-LIVER; ACETAMINOPHEN; FORMS; AMAP; 3'-HYDROXYACETANILIDE

Авторы

McGregor L. ^1,2 , Rychkov D.A. ^2,3 , Coster P.L. ¹ , Day S. ⁵ , Drebushchak V.A. ^2,4 , Achkasov A.F. ² , Nichol G.S. ¹ , Pulham C.R. ¹ , Boldyreva E.V. ^2,3

Организации

1	School of Chemistry and Centre for Science at Extreme Conditions, University of Edinburgh, King's Buildings, David Brewster Road, Edinburgh, United Kingdom
2	REC-008, Novosibirsk State University, Pirogova, 2, Novosibirsk, Russian Federation
3	Institute of Solid State Chemistry and Mechanochemistry, Kutateladze 18, Novosibirsk, Russian Federation
4	V.S. Sobolev Institute of Geology and Mineralogy, Russian Academy of Sciences, Pr. Ak. Koptyuga, 3, Novosibirsk, Russian Federation
5	Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, United Kingdom

Информация о финансировании (4)

1	The University of Edinburgh
2	Philosophical Society of Edinburgh
3	Министерство образования и науки Российской Федерации	1828
4	Президиум РАН

Metacetamol is a structural isomer of the widely used drug paracetamol and is being considered as a promising alternative to the latter because of its lower toxicity. Due to the importance of the well-known polymorphism of paracetamol, an investigation of the polymorphism of metacetamol was successfully undertaken. A new polymorph of metacetamol has been discovered and extensively characterised using a variety of analytical techniques (IR- and Raman spectroscopy, UV-visible optical spectroscopy, X-ray powder and single-crystal diffraction, TGA and DSC). A procedure for the reliable and reproducible preparation of the new polymorph is described. Its properties and crystal structure are compared with those of the previously known polymorph, as well as with those of paracetamol.

McGregor L. , Rychkov D.A. , Coster P.L. , Day S. , Drebushchak V.A. , Achkasov A.F. , Nichol G.S. , Pulham C.R. , Boldyreva E.V.
A New Polymorph of Metacetamol

CrystEngComm. 2015. V.17. N32. P.6183-6192. DOI: 10.1039/c5ce00910c WOS Scopus РИНЦ CAPlusCA OpenAlex

Полный текст от издателя

Поступила в редакцию:	8 мая 2015 г.
Принята к публикации:	12 июл. 2015 г.
Опубликована online:	14 июл. 2015 г.

Web of science:	WOS:000358915300015
Scopus:	2-s2.0-84938490728
РИНЦ:	23995688
Chemical Abstracts:	2015:1161440
Chemical Abstracts (print):	168:311493
OpenAlex:	W2111755688

БД	Цитирований
Web of science	27
Scopus	26
OpenAlex	27