A New Polymorph of Metacetamol | Sciact - CRIS-system of Boreskov Institute of Catalysis

A New Polymorph of Metacetamol Full article

Journal

CrystEngComm
ISSN: 1466-8033

Output data

Year: 2015, Volume: 17, Number: 32, Pages: 6183-6192 Pages count : 10 DOI: 10.1039/c5ce00910c

Tags

INDUCED LIVER-INJURY; NONHEPATOTOXIC REGIOISOMER; ORTHORHOMBIC PARACETAMOL; PARA-HYDROXYACETANILIDE; HIGH-PRESSURE; MOUSE-LIVER; ACETAMINOPHEN; FORMS; AMAP; 3'-HYDROXYACETANILIDE

Authors

McGregor L. ^1,2 , Rychkov D.A. ^2,3 , Coster P.L. ¹ , Day S. ⁵ , Drebushchak V.A. ^2,4 , Achkasov A.F. ² , Nichol G.S. ¹ , Pulham C.R. ¹ , Boldyreva E.V. ^2,3

Affiliations

1	School of Chemistry and Centre for Science at Extreme Conditions, University of Edinburgh, King's Buildings, David Brewster Road, Edinburgh, United Kingdom
2	REC-008, Novosibirsk State University, Pirogova, 2, Novosibirsk, Russian Federation
3	Institute of Solid State Chemistry and Mechanochemistry, Kutateladze 18, Novosibirsk, Russian Federation
4	V.S. Sobolev Institute of Geology and Mineralogy, Russian Academy of Sciences, Pr. Ak. Koptyuga, 3, Novosibirsk, Russian Federation
5	Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, United Kingdom

Funding (4)

1	The University of Edinburgh
2	Philosophical Society of Edinburgh
3	The Ministry of Education and Science of the Russian Federation	1828
4	Президиум РАН

Metacetamol is a structural isomer of the widely used drug paracetamol and is being considered as a promising alternative to the latter because of its lower toxicity. Due to the importance of the well-known polymorphism of paracetamol, an investigation of the polymorphism of metacetamol was successfully undertaken. A new polymorph of metacetamol has been discovered and extensively characterised using a variety of analytical techniques (IR- and Raman spectroscopy, UV-visible optical spectroscopy, X-ray powder and single-crystal diffraction, TGA and DSC). A procedure for the reliable and reproducible preparation of the new polymorph is described. Its properties and crystal structure are compared with those of the previously known polymorph, as well as with those of paracetamol.

McGregor L. , Rychkov D.A. , Coster P.L. , Day S. , Drebushchak V.A. , Achkasov A.F. , Nichol G.S. , Pulham C.R. , Boldyreva E.V.
A New Polymorph of Metacetamol

CrystEngComm. 2015. V.17. N32. P.6183-6192. DOI: 10.1039/c5ce00910c WOS Scopus РИНЦ ANCAN OpenAlex

Full text from publisher

Submitted:	May 8, 2015
Accepted:	Jul 12, 2015
Published online:	Jul 14, 2015

Web of science:	WOS:000358915300015
Scopus:	2-s2.0-84938490728
Elibrary:	23995688
Chemical Abstracts:	2015:1161440
Chemical Abstracts (print):	168:311493
OpenAlex:	W2111755688

DB	Citing
Web of science	27
Scopus	26
OpenAlex	27