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Mechanical Properties and Biological Behavior of 3D Matrices Produced by Electrospinning from Protein-Enriched Polyurethane Научная публикация

Журнал BioMed Research International
ISSN: 2314-6133 , E-ISSN: 2314-6141
Вых. Данные Год: 2018, Том: 2018, Номер статьи : 1380606, Страниц : 10 DOI: 10.1155/2018/1380606
Ключевые слова HUMAN ENDOTHELIAL-CELLS; TISSUE ENGINEERING APPLICATIONS; VASCULAR GRAFT; TECOPHILIC/GELATIN NANOFIBERS; SURFACE-ROUGHNESS; IN-VITRO; SCAFFOLDS; GELATIN; DEGRADATION; RELEASE
Авторы Chernonosova Vera S. 1,2 , Gostev Alexander A. 2 , Gao Yun 3 , Chesalov Yuriy A. 4 , Shutov Alexey V. 5 , Pokushalov Evgeniy A. 2 , Karpenko Andrey A. 2 , Laktionov Pavel P. 1,2
Организации
1 Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, Russia
2 Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Novosibirsk 630055, Russia
3 Novosibirsk State University, Novosibirsk 630090, Russia
4 Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia
5 Lavrentyev Institute of Hydrodynamics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia

Информация о финансировании (1)

1 Российский научный фонд 17-75-30009

Реферат: Properties of matrices manufactured by electrospinning from solutions of polyurethane Tecoflex EG-80A with gelatin in 1,1,1,3,3,3-hexafluoroisopropanol were studied. The concentration of gelatin added to the electrospinning solution was shown to influence the mechanical properties of matrices: the dependence of matrix tensile strength on protein concentration is described by a bell-shaped curve and an increase in gelatin concentration added to the elasticity of the samples. SEM, FTIR spectroscopy, and mechanical testing demonstrate that incubation of matrices in phosphate buffer changes the structure of the fibers and alters the polyurethane-gelatin interactions, increasing matrix durability. The ability of the matrices to maintain adhesion and proliferation of human endothelial cells was studied. The results suggest that matrices made of 3% polyurethane solution with 15% gelatin (wt/wt) and treated with glutaraldehyde are the optimal variant for cultivation of endothelial cells.
Библиографическая ссылка: Chernonosova V.S. , Gostev A.A. , Gao Y. , Chesalov Y.A. , Shutov A.V. , Pokushalov E.A. , Karpenko A.A. , Laktionov P.P.
Mechanical Properties and Biological Behavior of 3D Matrices Produced by Electrospinning from Protein-Enriched Polyurethane
BioMed Research International. 2018. V.2018. 1380606 :1-10. DOI: 10.1155/2018/1380606 WOS Scopus РИНЦ CAPlus PMID OpenAlex
Файлы: Полный текст от издателя
Даты:
Поступила в редакцию: 6 мар. 2018 г.
Принята к публикации: 29 мая 2018 г.
Опубликована online: 26 июн. 2018 г.
Опубликована в печати: 26 июл. 2018 г.
Идентификаторы БД:
Web of science: WOS:000436187300001
Scopus: 2-s2.0-85049830964
РИНЦ: 35777178
Chemical Abstracts: 2018:2263778
PMID (PubMed): 30046587
OpenAlex: W2809826731
Цитирование в БД:
БД Цитирований
Web of science 23
Scopus 24
РИНЦ 23
OpenAlex 25
Альметрики: