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Discrepancy between Thermodynamic and Kinetic Stabilities of the tert-Butanol Hydrates and Its Implication for Obtaining Pharmaceutical Powders by Freeze-Drying Научная публикация

Журнал Chemical Communications
ISSN: 1359-7345 , E-ISSN: 1364-548X
Вых. Данные Год: 2019, Том: 55, Номер: 29, Страницы: 4262-4265 Страниц : 4 DOI: 10.1039/C9CC00397E
Ключевые слова BUTYL ALCOHOL; PROCESS PERFORMANCE; QUALITY ATTRIBUTES; COSOLVENT SYSTEMS; ICE NUCLEATION; PHASE-DIAGRAM; LYOPHILIZATION; DESIGN
Авторы Ogienko A.G. 1,2 , Stoporev A.S. 1,2,3 , Ogienko A.A. 1,4 , Mel’gunov M.S. 2,5 , Adamova T.P. 1 , Yunoshev A.S. 2,6 , Manakov A.Yu. 1,2 , Boldyreva E.V. 2,5
Организации
1 Nikolaev Institute of Inorganic Chemistry SB RAS, 630090 Novosibirsk, Russia
2 Novosibirsk State University, 630090 Novosibirsk, Russia
3 Department of Physical and Colloid Chemistry, Gubkin University, 119991, Moscow, Russia
4 Institute of Molecular and Cellular Biology SB RAS, 630090 Novosibirsk, Russia
5 Boreskov Institute of Catalysis SB RAS, 630090 Novosibirsk, Russia
6 Lavrentiev Institute of Hydrodynamics SB RAS, 630090 Novosibirsk, Russia.

Информация о финансировании (2)

1 Министерство науки и высшего образования Российской Федерации (с 15 мая 2018) 0239-2019-0003
2 Российский фонд фундаментальных исследований 17-03-00784 (АААА-А17-117040710138-5)

Реферат: The tert-butanol (TBA) – water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).
Библиографическая ссылка: Ogienko A.G. , Stoporev A.S. , Ogienko A.A. , Mel’gunov M.S. , Adamova T.P. , Yunoshev A.S. , Manakov A.Y. , Boldyreva E.V.
Discrepancy between Thermodynamic and Kinetic Stabilities of the tert-Butanol Hydrates and Its Implication for Obtaining Pharmaceutical Powders by Freeze-Drying
Chemical Communications. 2019. V.55. N29. P.4262-4265. DOI: 10.1039/C9CC00397E WOS Scopus РИНЦ CAPlus OpenAlex
Даты:
Поступила в редакцию: 16 янв. 2019 г.
Принята к публикации: 18 мар. 2019 г.
Опубликована online: 19 мар. 2019 г.
Опубликована в печати: 14 апр. 2019 г.
Идентификаторы БД:
Web of science: WOS:000467970400026
Scopus: 2-s2.0-85064038707
РИНЦ: 38680252
Chemical Abstracts: 2019:515681
OpenAlex: W2922947576
Цитирование в БД:
БД Цитирований
Scopus 8
Web of science 8
РИНЦ 7
OpenAlex 8
Альметрики: